Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function
  • Metaadatok
Tartalom: http://real.mtak.hu/36231/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function
Létrehozó:
Telbisz, Ágnes Måria
Homolya, LĂĄszlĂł
Kiadó:
Taylor and Francis Group
Dátum:
2016
Téma:
QH301 Biology / biolĂłgia
QH3015 Molecular biology / molekulĂĄris biolĂłgia
Tartalmi leírás:
ntroduction: The bile salt export pump (BSEP/ABCB11), residing in the apical membrane of hepatocyte, mediates the secretion of bile salts into the bile. A range of human diseases is associated with the malfunction of BSEP, including fatal hereditary liver disorders and mild cholestatic conditions. Manifestation of these diseases primarily depends on the mutation type; however, other factors such as hormonal changes and drug interactions can also trigger or influence the related diseases.
Areas covered: Here, we summarize the recent knowledge on BSEP by covering its transport properties, cellular localization, regulation and major mutations/polymorphisms, as well as the hereditary and acquired diseases associated with BSEP dysfunction. We discuss the different model expression systems employed to understand the function of the BSEP variants, their drug interactions and the contemporary therapeutic interventions.
Expert opinion: The limitations of the available model expression systems for BSEP result in controversial conclusions, and obstruct our deeper insight into BSEP deficiencies and BSEP-related drug interactions. The knowledge originating from different methodologies, such as clinical studies, molecular genetics, as well as in vitro and in silico modeling, should be integrated and harmonized. Increasing availability of robust molecular biological tools and our better understanding of the mechanism of BSEP deficiencies should make the personalized, mutation-based therapeutic interventions more attainable.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Telbisz, Ágnes Måria and Homolya, Låszló (2016) Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function. EXPERT OPINION ON THERAPEUTIC TARGETS, 20 (4). pp. 501-514. ISSN 1472-8222
Kapcsolat:
MTMT:2979774; doi:10.1517/14728222.2016.1102889