Pathophysiological and clinical approach to cirrhotic cardiomyopathy.
  • Metaadatok
Tartalom: http://real.mtak.hu/15014/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Pathophysiological and clinical approach to cirrhotic cardiomyopathy.
Létrehozó:
PĂĄll, Alida
Czifra, Árpåd
Vitalis, Zsuzsanna
Papp, MĂĄria
Paragh, GyĂśrgy
SzabĂł, ZoltĂĄn
Kiadó:
Romanian Societies of Gastroenterology
Dátum:
2014-09
Téma:
R1 Medicine (General) / orvostudomĂĄny ĂĄltalĂĄban
RC Internal medicine / belgyĂłgyĂĄszat
Tartalmi leírás:
Hyperdynamic circulation, systolic and diastolic left ventricular dysfunction and certain electrophysiological
abnormalities have been associated with cirrhosis and known for a long time. These clinical features have been
introduced as cirrhotic cardiomyopathy (CCM), which is characterized by blunted myocardial contractile
responsiveness to physical, physiological and pharmacological stress. Importantly, cardiac dysfunction
can be reversible and can improve due to effective medical treatment and also after liver transplantation.
Echocardiography and electrocardiography are essential tools for recognizing the characteristic changes in
the myocardial function and also the alterations in the electrophysiological properties of the heart. Laboratory
markers are auxiliary modalities further aiding the establishment of the correct diagnosis. In this review, we
aimed to collect the pathophysiological background and clinical characteristics of CCM with the intention
of summarizing the current possibilities for the diagnosis establishment and treatment of this cardio-hepatic
disorder.
Key words:
liver cirrhosis – cardiomyopathy – heart failure – arrhythmias.
Abbreviations
: A: late diastolic transmitral peak flow velocity; ACE: angiotensin converting enzyme; ANP:
atrial natriuretic peptide; ARB: angiotensin receptor blocker; BNP: brain natriuretic peptide; cAMP: cyclic
adenosine monophosphate; CCM: cirrhotic cardiomyopathy; CGRP: calcitonin gene-related peptide; CO:
carbon monoxide; DD: diastolic dysfunction; DT: deceleration time; E: early diastolic transmitral peak flow
velocity; Ea: early diastolic velocity of the septal mitral annulus; EF: ejection fraction; MUGA: Multi Gated
Acquisition Scan; NO: nitric oxide; NSBB: non-selective beta-blocker; pro-BNP: pro-brain natriuretic peptide;
QTc: corrected QT interval; RAAS: renin-angiotensin aldosterone system; RALES: Randomized Aldactone
Evaluation Study; suPAR: urokinase-type plasminogen activator receptor; TDI: Tissue Doppler Imaging; TIPS:
transjugular intrahepatic portosystemic shunt; TNF-alpha: tumor necrosis factor-alpha.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Påll, Alida and Czifra, Árpåd and Vitalis, Zsuzsanna and Papp, Måria and Paragh, GyÜrgy and Szabó, Zoltån (2014) Pathophysiological and clinical approach to cirrhotic cardiomyopathy. Journal of Gastrointestinal and Liver Diseases, 23 (3). pp. 301-310. ISSN 1841-8724
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