NDA@SZTAKI

A D-vitamin szerepe a krónikus szívelégtelenség kialakulásában [The role of vitamin D in the development of cardiac failure]

Szabó, Boglárka

Merkely, Béla Péter

Takács, István

Akadémiai Kiadó

2009

RC Internal medicine / belgyógyászat

Congestive heart failure is a chronic disease, whose incidence is especially growing in the subpopulation of elderly people. The majority of these patients have vitamin D levels in the insufficient range. Skin synthesis is the most important vitamin D source for humans. Congestive heart failure patients have relatively low outdoor activities. Consequently, a disease-related sedentary lifestyle is an important cause for the insufficient vitamin D status in patients. However, there is an accumulating body of evidence that vitamin D insufficiency plays a role in the etiology and pathogenesis of congestive heart failure. Vitamin D has direct effect on heart cells and indirect effect on the risk factors of the disease. Four major potential mechanisms may be important to explain the direct effects of vitamin D against congestive heart failure: the effect on myocardial contractile function, the regulation of natriuretic hormone secretion, the effect on extracellular matrix remodelling and the regulation of inflammation cytokines. It has been demonstrated that vitamin D has a high impact on congestive heart failure main risk factors as hypertension, renin-angiotensin system malfunction and atherosclerosis. In spite of the robust preclinical data only few clinical observations prove the positive effect of vitamin D on congestive heart failure.

angol

Article

PeerReviewed

info:eu-repo/semantics/article

text

http://real.mtak.hu/13916/1/1256866.pdf

Szabó, Boglárka and Merkely, Béla Péter and Takács, István (2009) A D-vitamin szerepe a krónikus szívelégtelenség kialakulásában [The role of vitamin D in the development of cardiac failure]. ORVOSI HETILAP, 150 (30). pp. 1397-1402. ISSN 0030-6002

http://real.mtak.hu/13916/

MTMT:1256866; doi:10.1556/OH.2009.28674