Alcohol stress, membranes, and chaperones
  • Metaadatok
Tartalom: http://real.mtak.hu/11276/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Alcohol stress, membranes, and chaperones
Létrehozó:
Tóth, Erzsébet Melinda
Vigh, László
Sántha, Miklós
Kiadó:
Springer Verlag
Dátum:
2014
Téma:
QH3011 Biochemistry / biokémia
QH3015 Molecular biology / molekuláris biológia
Tartalmi leírás:
Ethanol, which affects all body organs, exerts a number of cytotoxic effects, most of them independent of cell type. Ethanol treatment leads to increased membrane fluidity and to changes in membrane protein composition. It can also interact directly with membrane proteins, causing conformational changes and thereby influencing their function. The cytotoxic action may include an increased level of oxidative stress. Heat shock protein molecular chaperones are ubiquitously expressed evolutionarily conserved proteins which serve as critical regulators of cellular homeostasis. Heat shock proteins can be induced by various forms of stresses such as elevated temperature, alcohol treatment, or ischemia, and they are also upregulated in certain pathological conditions. As heat shock and ethanol stress provoke similar responses, it is likely that heat shock protein activation also has a role in the protection of membranes and other cellular components during alcohol stress.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Tóth, Erzsébet Melinda and Vigh, László and Sántha, Miklós (2014) Alcohol stress, membranes, and chaperones. CELL STRESS & CHAPERONES, 19 (3). pp. 299-309. ISSN 1355-8145
Kapcsolat:
MTMT:2527717; doi:10.1007/s12192-013-0472-5