Urocortin 2 treatment is protective in excitotoxic retinal degeneration
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Tartalom: http://real.mtak.hu/9638/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Urocortin 2 treatment is protective in excitotoxic retinal degeneration
Létrehozó:
Szabadfi, Krisztina
Kiss, PĂ©ter
Reglődi, Dóra
Fekete, Éva
Tamás, Andrea
Dányádi, Bese
Atlasz, Tamás
Gábriel, Róbert
Kiadó:
Akadémiai Kiadó
Dátum:
2014
Téma:
QP Physiology / Ă©lettan
Tartalmi leírás:
Urocortin 2 (Ucn 2) is a corticotrop releasing factor paralog peptide with many physiological functions and it has
widespread distribution. There are some data on the cytoprotective effects of Ucn 2, but less is known about its
neuro- and retinoprotective actions. We have previously shown that Ucn 2 is protective in ischemia-induced retinal
degeneration. The aim of the present study was to examine the protective potential of Ucn 2 in monosodiumglutamate
(MSG)-induced retinal degeneration by routine histology and to investigate cell-type specific effects by
immunohistochemistry. Rat pups received MSG applied on postnatal days 1, 5 and 9 and Ucn 2 was injected
intravitreally into one eye. Retinas were processed for histology and immunocytochemistry after 3 weeks.
Immunolabeling was determined for glial fibrillary acidic protein, vesicular glutamate transporter 1, protein kinase
Cα, calbindin, parvalbumin and calretinin.
Retinal tissue from animals treated with MSG showed severe degeneration compared to normal retinas, but
intravitreal Ucn 2 treatment resulted in a retained retinal structure both at histological and neurochemical levels:
distinct inner retinal layers and rescued inner retinal cells (different types of amacrine and rod bipolar cells) could
be observed. These findings support the neuroprotective function of Ucn 2 in MSG-induced retinal degeneration.
Nyelv:
magyar
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
text
Azonosító:
Szabadfi, Krisztina and Kiss, Péter and Reglődi, Dóra and Fekete, Éva and Tamás, Andrea and Dányádi, Bese and Atlasz, Tamás and Gábriel, Róbert (2014) Urocortin 2 treatment is protective in excitotoxic retinal degeneration. Acta Physiologica Hungarica, 101 (1). pp. 67-76. ISSN 0231-424X, ESSN: 1588-2683
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