lGnRH-III - a Promising Candidate for Anticancer Drug Development
  • Metaadatok
Tartalom: http://real.mtak.hu/9341/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
lGnRH-III - a Promising Candidate for Anticancer Drug Development
Létrehozó:
Manea, Marilena
Mező, Gábor
Kiadó:
Bentham Science Publishers
Dátum:
2013
Téma:
QD04 Organic chemistry / szerves kémia
RM Therapeutics. Pharmacology / terápia, gyógyszertan
Tartalmi leírás:
Lamprey gonadotropin-releasing hormone-III (lGnRH-III; Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2), a
native isoform of human GnRH (GnRH-I), was initially isolated from the brain of the sea lamprey (Petromyzon marinus).
It is a weak GnRH agonist, which exerts a direct antiproliferative effect on cancer cells and has an insignificant LH and
FSH releasing potency in mammals. These features reveal the advantages of lGnRH-III and its derivatives for use in can-cer therapy. Here we give an overview of various strategies to increase the antitumor activity of lGnRH-III, such as amino
acid replacement, cyclization, dimerization and conjugation to polymers or to chemotherapeutic agents. In vitroand in
vivoantitumor activity of lGnRH-III based compounds was demonstrated both on hormone dependent and independent
tumors.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Manea, Marilena and Mező, Gábor (2013) lGnRH-III - a Promising Candidate for Anticancer Drug Development. Protein and Peptide Letters, 20 (4). pp. 439-449. ISSN ISSN: 1875-5305 (Online), ISSN: 0929-8665 (Print)
Kapcsolat:
DOI: 10.2174/0929866511320040008
-