The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells
  • Metaadatok
Tartalom: http://dx.doi.org/10.1007/s00018-015-2056-2
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells
Létrehozó:
Baricza, Eszter
Tamási, Viola
Marton, Nikolett
Buzás, Edit Irén
Nagy, György
Dátum:
2016-01
Téma:
R1 Medicine (General) / orvostudomány általában
R850-854 Experimental medicine / kisérleti orvostudomány
Tartalmi leírás:
The aryl hydrocarbon receptor (AHR) is a cytoplasmic transcription factor, which plays an essential role in the xenobiotic metabolism in a wide variety of cells. The AHR gene is evolutionarily conserved and it has a central role not only in the differentiation and maturation of many tissues, but also in the toxicological metabolism of the cell by the activation of metabolizing enzymes. Several lines of evidence support that both AHR agonists and antagonists have profound immunological effects; and recently, the AHR has been implicated in antibacterial host defense. According to recent studies, the AHR is essential for the differentiation and activation of T helper 17 (Th17) cells. It is well known that Th17 cells have a central role in the development of inflammation, which is crucial in the defense against pathogens. In addition, Th17 cells play a major role in the pathogenesis of several autoimmune diseases such as rheumatoid arthritis. Therefore, the AHR may provide connection between the environmental chemicals, the immune regulation, and autoimmunity. In the present review, we summarize the role of the AHR in the Th17 cell functions.
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Baricza, Eszter and Tamási, Viola and Marton, Nikolett and Buzás, Edit Irén and Nagy, György (2016) The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells. Cellular and Molecular Life Sciences, 73 (1). pp. 95-117. ISSN 1420-9071
Kapcsolat:
FP7 COST ME HAD BM1202, FP7 Marie Curie ITN ??DYNANO"