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Bioisosteric hybrids of two anti-inflammatory agents, rutaecarpine and piroxicam

  • Metaadatok
Tartalom: http://dx.doi.org/10.1016/j.tetlet.2008.07.098
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Bioisosteric hybrids of two anti-inflammatory agents, rutaecarpine and piroxicam
Létrehozó:
Bubenyák, Máté Dániel
Noszál, Béla
Kóczián, Kristóf
Takács, Mária
Béni, Szabolcs
Hermecz, István
Kökösi, József
Dátum:
2008
Téma:
RM Therapeutics. Pharmacology / terápia, gyógyszertan
RS Pharmacy and materia medica / gyógyszerészet, gyógyászati eszközök
Tartalmi leírás:
Bioisosteric replacements were accomplished by building the structural elements of piroxicam, an antiinflammatory drug, into the pentacyclic system of rutaecarpine, a quinazolinocarboline alkaloid, in order to modify activity and selectivity on COX-isoenzymes. The pentacyclic compounds were synthesized efficiently by employing 1-oxo-9,10,11,12-tetrahydro-4H-pyrido[1,2-b] 1,2-benzothiazine 5,5-dioxide as a key intermediate, and prepared by alternative routes. Condensation of the tricyclic ketone with arylhydrazines and subsequent Fischer-indolization provided the first representatives of new heterocyclic ring systems 3 and 4. Crown Copyright (C) 2008 Published by Elsevier Ltd. All Fights reserved.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Bubenyák, Máté Dániel and Noszál, Béla and Kóczián, Kristóf and Takács, Mária and Béni, Szabolcs and Hermecz, István and Kökösi, József (2008) Bioisosteric hybrids of two anti-inflammatory agents, rutaecarpine and piroxicam. TETRAHEDRON LETTERS, 49 (40). pp. 5711-5713. ISSN 0040-4039
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