| Tartalom: |
http://dx.doi.org/10.4155/fmc.15.156 |
| Archívum: |
MTA Könyvtár |
| Gyűjtemény: |
Status = Published
Type = Article
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| Cím: |
The design of multitarget ligands for chronic and neuropathic pain
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| Létrehozó: |
Dvorácskó, Szabolcs
Stefanucci, Azzurra
Novellino, Ettore
Mollica, Adriano
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| Dátum: |
2015
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| Téma: |
QH3011 Biochemistry / biokémia
RM Therapeutics. Pharmacology / terápia, gyógyszertan
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| Tartalmi leírás: |
Background: Monodrug therapy has been used with success to fight various pathologies. When one medicine fails, co-administration of two or more drugs at the same time may be successfully applied in the treatment of infections, hypertension, HIV and in many other fields. Discussion: This approach has some weakness related to the pharmacokinetic of the two different substances administered, side effects, possible drug-drug interaction. Bivalent ligand approach would maintain the strength of the multidrug therapy (synergistic effect, lower doses, and little side effects) and overcome the weakness of a co-administration. Conclusion: In this review we have described the state-of-the-art of the multitarget approach for the control of pain. Several approaches adopted by different research groups and future perspectives have been discussed. © 2015 Future Science Ltd.
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| Típus: |
Article
PeerReviewed
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| Formátum: |
text
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| Azonosító: |
Dvorácskó, Szabolcs and Stefanucci, Azzurra and Novellino, Ettore and Mollica, Adriano (2015) The design of multitarget ligands for chronic and neuropathic pain. Future Medicinal Chemistry, 7 (18). pp. 2469-2483. ISSN 1756-8919
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