NDA@SZTAKI

Aptasensors for viral diagnostics

Kieboom, Corné H. van den

Beek, Samantha L. van der

Mészáros, Tamás

Gyurcsányi, Ervin Róbert

Ferwerda, Gerben

Elsevier

2015

QD Chemistry / kémia

QR355 Virology / víruskutatás

Novel viral diagnostic tools need to be affordable, fast,
accurate and easy to use with sensitivity and specificity
equivalent or superior to current standards. At present, viral
diagnostics are based on direct detection of viral components or
indirect detection by measuring antibodies generated in response
to viral infection. While sensitivity of detection and
quantification are still important challenges, we expect major
advances from new assay formats and synthetic binding molecules,
such as aptamers. Compared to traditional antibody-based
detection, aptamers could provide faster adaptation to
continuously evolving virus strains and higher discriminating
capacity between specific virus serotypes. Aptamers are very
stable and easily modifiable, so are ideal molecules for
detection and chemical sensing applications. Here, we review the
use of aptasensors for detection of viral pathogens and consider
the feasibility of aptasensors to become standard devices for
point-of-care diagnostics of viruses. © 2015.

angol

Article

PeerReviewed

info:eu-repo/semantics/article

text

http://real.mtak.hu/32536/1/1_s2.0_S0165993615002435_main_u...

Kieboom, Corné H. van den and Beek, Samantha L. van der and Mészáros, Tamás and Gyurcsányi, Ervin Róbert and Ferwerda, Gerben (2015) Aptasensors for viral diagnostics. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 74. pp. 58-67. ISSN 0165-9936

http://real.mtak.hu/32536/

http://dx.doi.org/10.1016/j.trac.2015.05.012

MTMT:2969421; doi:10.1016/j.trac.2015.05.012