Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: role of Rac and PI3K. (NDA@SZTAKI, Nemzeti Digitális Adattár, National Digital Data Archive)

Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: role of Rac and PI3K.

Metaadatok

Tartalom:	http://real.mtak.hu/32268/
Archívum:	MTA Könyvtár
Gyûjtemény:	Status = Published Type = Article
Cím:	Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: role of Rac and PI3K.
Létrehozó:	MolnÃ¡r, Judit Fazakas, Csilla HaskÃ³, JÃ¡nos Sipos, Orsolya Nagy, KÃ¡roly NyÃºl-TÃ³th, ÃdÃ¡m Farkas, Elek Attila VÃ©gh, Attila Gergely VÃ¡rÃ³, GyÃ¶rgy Galajda, PÃ©ter Krizbai, IstvÃ¡n AdorjÃ¡n Wilhelm, Imola MÃ¡ria
Kiadó:	Landes Bioscience
Dátum:	2016
Téma:	RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkolÃ³gia
Tartalmi leírás:	Brain metastases are common and devastating complications of both breast cancer and melanoma. Although mammary carcinoma brain metastases are more frequent than those originating from melanoma, this latter has the highest tropism to the brain. Using static and dynamic in vitro approaches, here we show that melanoma cells have increased adhesion to the brain endothelium in comparison to breast cancer cells. Moreover, melanoma cells can transmigrate more rapidly and in a higher number through brain endothelial monolayers than breast cancer cells. In addition, melanoma cells have increased ability to impair tight junctions of cerebral endothelial cells. We also show that inhibition of Rac or PI3K impedes adhesion of breast cancer cells and melanoma cells to the brain endothelium. In addition, inhibition of Rac or PI3K inhibits the late phase of transmigration of breast cancer cells and the early phase of transmigration of melanoma cells. On the other hand, the Rac inhibitor EHT1864 impairs the junctional integrity of the brain endothelium, while the PI3K inhibitor LY294002 has no damaging effect on interendothelial junctions. We suggest that targeting the PI3K/Akt pathway may represent a novel opportunity in preventing the formation of brain metastases of melanoma and breast cancer.
Nyelv:	angol
Típus:	Article PeerReviewed info:eu-repo/semantics/article
Formátum:	text
Azonosító:	http://real.mtak.hu/32268/1/MolnarCellAdhMigr.pdf MolnÃ¡r, Judit and Fazakas, Csilla and HaskÃ³, JÃ¡nos and Sipos, Orsolya and Nagy, KÃ¡roly and NyÃºl-TÃ³th, ÃdÃ¡m and Farkas, Elek Attila and VÃ©gh, Attila Gergely and VÃ¡rÃ³, GyÃ¶rgy and Galajda, PÃ©ter and Krizbai, IstvÃ¡n AdorjÃ¡n and Wilhelm, Imola MÃ¡ria (2016) Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: role of Rac and PI3K. CELL ADHESION & MIGRATION. ISSN 1933-6918
Kapcsolat:	http://real.mtak.hu/32268/ MTMT:2995413; doi:10.1080/19336918.2015.1122156