The expression of inflammatory cytokines, TAM tyrosine kinase receptors and their ligands is upregulated in venous leg ulcer patients: A novel insight into chronic wound immunity
  • Metaadatok
Tartalom: http://real.mtak.hu/29728/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
The expression of inflammatory cytokines, TAM tyrosine kinase receptors and their ligands is upregulated in venous leg ulcer patients: A novel insight into chronic wound immunity
Létrehozó:
Filkor, Kata
NĂ©meth, Tibor
Nagy, István
Kondorosi, Éva
Urbán, Edit
Kemény, Lajos
Szolnoky, Győző
Dátum:
2015
Téma:
R1 Medicine (General) / orvostudomány általában
RD Surgery / sebészet
Tartalmi leírás:
The systemic host defence mechanisms, especially innate immunity, in venous leg ulcer patients are poorly investigated. The aim of the current study was to measure Candida albicans killing activity and gene expressions of pro- and anti-inflammatory cytokines and innate immune response regulators, TAM receptors and ligands of peripheral blood mononuclear cells separated from 69 venous leg ulcer patients and 42 control probands. Leg ulcer patients were stratified into responder and non-responder groups on the basis of wound healing properties. No statistical differences were found in Candida killing among controls, responders and non-responders. Circulating blood mononuclear cells of patients overexpress pro-inflammatory (IL-1α, TNFα, CXCL-8) and anti-inflammatory (IL-10) cytokines as well as TAM receptors (Tyro, Axl, MerTK) and their ligands Gas6 and Protein S compared with those of control individuals. IL-1α is notably overexpressed in venous leg ulcer treatment non-responders; in contrast, Axl gene expression is robustly stronger among responders. These markers may be considered as candidates for the prediction of treatment response among venous leg ulcer patients. © 2015 Medicalhelplines.com Inc and John Wiley & Sons Ltd.
Nyelv:
angol
Típus:
Article
NonPeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Filkor, Kata and Németh, Tibor and Nagy, István and Kondorosi, Éva and Urbán, Edit and Kemény, Lajos and Szolnoky, Győző (2015) The expression of inflammatory cytokines, TAM tyrosine kinase receptors and their ligands is upregulated in venous leg ulcer patients: A novel insight into chronic wound immunity. INTERNATIONAL WOUND JOURNAL. pp. 1-13. ISSN 1742-4801
Kapcsolat:
https://dx.doi.org/10.1111/iwj.12473
MTMT:2941825; doi:10.1111/iwj.12473