Multinucleated Giant Hemocytes Are Effector Cells in Cell-Mediated Immune Responses of Drosophila
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Tartalom: http://real.mtak.hu/29315/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Multinucleated Giant Hemocytes Are Effector Cells in Cell-Mediated Immune Responses of Drosophila
Létrehozó:
Márkus, Róbert
Lerner, Zita
Honti, Viktor
Csordás, Gábor
Zsámboki, János
Cinege, Gyöngyi
Párducz, Árpád
Lukacsovich, Tamás
Kurucz, Judit Éva
Andó, István
Dátum:
2015
Téma:
QH301 Biology / biológia
QR180 Immunology / immunológia
Tartalmi leírás:
We identified and characterized a so far unrecognized cell type, dubbed the multinucleated giant hemocyte (MGH), in the ananassae subgroup of Drosophilidae. Here, we describe the functional and ultrastructural characteristics of this novel blood cell type as well as its characterization with a set of discriminative immunological markers. MGHs are encapsulating cells that isolate and kill the parasite without melanization. They share some properties with but differ considerably from lamellocytes, the encapsulating cells of Drosophila melanogaster, the broadly used model organism in studies of innate immunity. MGHs are nonproliferative effector cells that are derived from phagocytic cells of the sessile tissue and the circulation, but do not exhibit phagocytic activity. In contrast to lamellocytes, MGHs are gigantic cells with filamentous projections and contain many nuclei, which are the result of the fusion of several cells. Although the structure of lamellocytes and MGHs differ remarkably, their function in the elimination of parasites is similar, which is potentially the result of the convergent evolution of interactions between hosts and parasites in different geographic regions. MGHs are highly motile and share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation. © 2015 S. Karger AG, Basel
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Márkus, Róbert and Lerner, Zita and Honti, Viktor and Csordás, Gábor and Zsámboki, János and Cinege, Gyöngyi and Párducz, Árpád and Lukacsovich, Tamás and Kurucz, Judit Éva and Andó, István (2015) Multinucleated Giant Hemocytes Are Effector Cells in Cell-Mediated Immune Responses of Drosophila. JOURNAL OF INNATE IMMUNITY, 7 (4). pp. 340-353. ISSN 1662-811X
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