NDA@SZTAKI

Anti-irritant and anti-inflammatory effects of glycerol and xylitol in sodium lauryl sulphate-induced acute irritation

Szél, Edit

Polyánka, Hilda

Szabó, Kornélia

Hartmann, Petra

Degovics, Döníz

Balázs, Boglárka

Németh, István Balázs

Korponyai, Csilla

Csányi, Erzsébet

Kaszaki, JĂłzsef

Dikstein, Shabtai

Nagy, Katalin

Kemény, Lajos

Erős, Gábor

Wiley

2015

RL Dermatology / bőrgyógyászat

Background Glycerol is known to possess anti-irritant and hydrating properties and previous studies suggested that
xylitol may also have similar effects.
Objective Our aim was to study whether different concentrations of these polyols restore skin barrier function and
soothe inflammation in sodium lauryl sulphate (SLS)-induced acute irritation.
Methods The experiments were performed on male SKH-1 hairless mice. The skin of the dorsal region was exposed to
SLS (5%) for 3 h alone or together with 5% or 10% of glycerol respectively. Further two groups received xylitol solutions
(8.26% and 16.52% respectively) using the same osmolarities, which were equivalent to those of the glycerol treatments.
The control group was treated with purified water. Transepidermal water loss (TEWL) and skin hydration were determined.
Microcirculatory parameters of inflammation were observed by means of intravital videomicroscopy (IVM). Furthermore,
accumulation of neutrophil granulocytes and lymphocytes, the expression of inflammatory cytokines and SLS
penetration were assessed, as well.
Results Treatment with the 10% of glycerol and both concentrations of xylitol inhibited the SLS-induced elevation of
TEWL and moderated the irritant-induced increase in dermal blood flow and in the number of leucocyte-endothelial interactions.
All concentrations of the applied polyols improved hydration and prevented the accumulation of lymphocytes
near the treatment site. At the mRNA level, neither glycerol nor xylitol influenced the expression of interleukin-1 alpha.
However, expression of interleukin-1 beta was significantly decreased by the 10% glycerol treatment, while expression
of tumour necrosis factor-alpha decreased upon the same treatment, as well as in response to xylitol. Higher polyol
treatments decreased the SLS penetration to the deeper layers of the stratum corneum.
Conclusion Both of the analysed polyols exert considerable anti-irritant and anti-inflammatory properties, but the
effective concentration of xylitol is lower than that of glycerol.

magyar

Article

NonPeerReviewed

info:eu-repo/semantics/article

text

http://real.mtak.hu/27980/2/SZELL_JEADV.pdf

Szél, Edit and Polyánka, Hilda and Szabó, Kornélia and Hartmann, Petra and Degovics, Döníz and Balázs, Boglárka and Németh, István Balázs and Korponyai, Csilla and Csányi, Erzsébet and Kaszaki, József and Dikstein, Shabtai and Nagy, Katalin and Kemény, Lajos and Erős, Gábor (2015) Anti-irritant and anti-inflammatory effects of glycerol and xylitol in sodium lauryl sulphate-induced acute irritation. Journal of the European Academy of Dermatology and Venereology : JEADV, 29 (12). pp. 2333-2341. ISSN 1468-3083

http://real.mtak.hu/27980/

http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%2914...