Transcriptional repression by MYB3R proteins regulates plant organ growth
  • Metaadatok
Tartalom: http://emboj.embopress.org/content/34/15/1992.long
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Transcriptional repression by MYB3R proteins regulates plant organ growth
Létrehozó:
Kobayashi, Kosuke
Suzuki, Toshiya
Iwata, Eriko
Nakamichi, Norihito
Suzuki, Takamasa
Chen, Poyu
Ohtani, Misato
Ishida, Takashi
Hosoya, Hanako
Müller, Sabine
Leviczky, Tünde
Pettkó-Szandtner, Aladár
Darula, Zsuzsanna
Iwamoto, Akitoshi
Nomoto, Mika
Tada, Yasuomi
Higashiyama, Tetsuya
Demura, Taku
Doonan, John H.
Hauser, Marie-Theres
Sugimoto, Keiko
Umeda, Masaaki
Magyar, Zoltán
Bögre, László
Ito, Masaki
Dátum:
2015-08-04
Téma:
Q1 Science (General) / természettudomány általában
Tartalmi leírás:
In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post-mitotic quiescent state during cell differentiation, it is important to repress genes with mitotic functions. We found that three of the Arabidopsis MYB3R transcription factors synergistically maintain G2/M-specific genes repressed in post-mitotic cells and restrict the time window of mitotic gene expression in proliferating cells. The combined mutants of the three repressor-type MYB3R genes displayed long roots, enlarged leaves, embryos, and seeds. Genome-wide chromatin immunoprecipitation revealed that MYB3R3 binds to the promoters of G2/M-specific genes and to E2F target genes. MYB3R3 associates with the repressor-type E2F, E2FC, and the RETINOBLASTOMA RELATED proteins. In contrast, the activator MYB3R4 was in complex with E2FB in proliferating cells. With mass spectrometry and pairwise interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies. In plants, these repressor complexes are important for periodic expression during cell cycle and to establish a post-mitotic quiescent state determining organ size.
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Kobayashi, Kosuke and Suzuki, Toshiya and Iwata, Eriko and Nakamichi, Norihito and Suzuki, Takamasa and Chen, Poyu and Ohtani, Misato and Ishida, Takashi and Hosoya, Hanako and Müller, Sabine and Leviczky, Tünde and Pettkó-Szandtner, Aladár and Darula, Zsuzsanna and Iwamoto, Akitoshi and Nomoto, Mika and Tada, Yasuomi and Higashiyama, Tetsuya and Demura, Taku and Doonan, John H. and Hauser, Marie-Theres and Sugimoto, Keiko and Umeda, Masaaki and Magyar, Zoltán and Bögre, László and Ito, Masaki (2015) Transcriptional repression by MYB3R proteins regulates plant organ growth. The EMBO Journal, 34 (15). pp. 1992-2007. ISSN 1460-2075
Kapcsolat:
037704
Létrehozó:
info:eu-repo/semantics/openAccess