An overview of peptide and peptoid foldamers in medicinal chemistry
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Tartalom: http://real.mtak.hu/27580/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
An overview of peptide and peptoid foldamers in medicinal chemistry
Létrehozó:
Mándity, István M.
Fülöp, Ferenc
Dátum:
2015-08-10
Téma:
QD04 Organic chemistry / szerves kémia
Tartalmi leírás:
INTRODUCTION
Foldamers are artificial self-organizing systems with various critical properties: i) a stable and designable secondary structure; ii) a larger molecular surface as compared with ordinary organic drug molecules; iii) appropriate control of the orientation of the side-chain functional groups; iv) resistance against proteolytic degradation, which leads to potentially increased oral bioavailability and a longer serum half-life relative to ordinary α-peptides; and v) the lower conformational freedom may result in increased receptor binding in comparison with the natural analogs. Areas covered: This article covers the general properties and types of foldamers. This includes highlighted examples of medicinal chemical applications, including antibacterial and cargo molecules, anti-Alzheimer compounds and protein-protein interaction modifiers. Expert opinion: Various new foldamers have been created with a range of structures and biological applications. Membrane-acting antibacterial foldamers have been introduced. A general property of these structures is their amphiphilic nature. The amphiphilicity can be stationary or induced by the membrane binding. Cell-penetrating foldamers have been described which serve as cargo molecules, and foldamers have been used as autophagy inducers. Anti-Alzheimer compounds too have been created and the greatest breakthrough was attained via the modification of protein-protein interactions. This can serve as the chemical and pharmaceutical basis for the relevance of foldamers in the future.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Mándity, István M. and Fülöp, Ferenc (2015) An overview of peptide and peptoid foldamers in medicinal chemistry. Expert opinion on drug discovery, 10. pp. 1-15. ISSN 1746-045X
Kapcsolat:
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