Xanthine Oxidase-Inhibitory Activity of Extracts Prepared from Polygonaceae Species
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Type = Article
Cím:
Xanthine Oxidase-Inhibitory Activity of Extracts Prepared from Polygonaceae Species
Létrehozó:
Orbán-Gyapai, Orsolya
Lajter, Ildikó
Hohmann, Judit
Jakab, Gusztáv
Vasas, Andrea
Dátum:
2014-12-16
Téma:
Q1 Science (General) / természettudomány általában
QD Chemistry / kémia
R1 Medicine (General) / orvostudomány általában
Tartalmi leírás:
The xanthine oxidase (XO)-inhibitory activity of aqueous and organic extracts of 27 selected species belonging in five genera (Fallopia, Oxyria, Persicaria, Polygonum and Rumex) of the family Polygonaceae occurring in the Carpathian Basin were tested in vitro. From different plant parts (aerial parts, leaves, flowers, fruits and roots) a total of 196 extracts were prepared by subsequent extraction with methanol and hot H2O, and solvent?solvent partition of the MeOH extract yielding n-hexane, chloroform and 50% MeOH subextracts. It was found that the chloroform subextracts and/or the remaining 50% MeOH extracts of Fallopia species (F. bohemica, F. japonica and F. sachalinensis), Rumex species (R. acetosa, R. acetosella, R. alpinus, R. conglomeratus, R. crispus, R. hydrolapathus, R. pulcher, R. stenophyllus, R. thyrsiflorus, R. obtusifolius subsp. subalpinus, R. patientia) and Polygonum bistorta, P. hydropiper P. lapathifolium and P. viviparum demonstrated the highest XO-inhibitory activity (> 85% inhibition) at 400 µg/mL. The IC50 values of the active extracts were also determined. On the basis of the results, these plants, and especially P. hydropiper and R. acetosella, are considered worthy of activity-guided phytochemical investigations.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Orbán-Gyapai, Orsolya and Lajter, Ildikó and Hohmann, Judit and Jakab, Gusztáv and Vasas, Andrea (2014) Xanthine Oxidase-Inhibitory Activity of Extracts Prepared from Polygonaceae Species. Phytotherapy Research, 29. pp. 459-465. ISSN 0951-418X
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