NDA@SZTAKI

Novel carboxylated PEG-coating on magnetite nanoparticles designed for biomedical applications

NyergesnĂŠ IllĂŠs, ErzsĂŠbet

CsĂĄkinĂŠ TombĂĄcz, Etelka

Szekeres, MĂĄrta

TĂłth, IldikĂł

Szabó, Ákos

IvĂĄn, BĂŠla

2015

QD02 Physical chemistry / fizikai kĂŠmia

Fabrication of PEG coating on magnetite nanoparticles (MNPs) is one of the most
favoured ways to ensure biocompatibility. Surface modification of magnetite by an
own
-
prepared comb
-
like PEG
-
copolymer (PEGA
-
AA) was
compared with two
commercially available ones (carboxy
-
PEG (PEG
-
C) and phosphate
-
PEG (PEG
-
P)).
ATR FTIR data revealed that all polymers form complexes on the surface of MNPs.
Electrophoresis and dynamic light scattering (DLS) experiments showed that both
the
type and quantity of the polymers
’ anchoring groups i
nfluence the aggregation of
coated nanomagnets. PEG
-
C shell does not provide excess negative charges, so
magnetite particles became aggregated. However PEG
-
P and PEGA
-
AA gradually
modify the surface:
neutralizing the originally positively charged MNPs below loading
0.5 mmol/g, while above it a polyanionic layer forms on nanomagnets dispersing them
in salty media at pH ~6.5. The PEGA
-
AA comb
-
like copolymer is more efficient for
MNPs PEGylation due to t
he uniform distribution of carboxylates and PEG chains
along the carbon skeleton.

angol

Article

PeerReviewed

info:eu-repo/semantics/article

text

http://real.mtak.hu/25674/1/ManuscriptHLGA_IllesE_revised_u...

NyergesnÊ IllÊs, ErzsÊbet and CsåkinÊ Tombåcz, Etelka and Szekeres, Mårta and Tóth, Ildikó and Szabó, Ákos and Ivån, BÊla (2015) Novel carboxylated PEG-coating on magnetite nanoparticles designed for biomedical applications. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 380. pp. 132-139. ISSN 0304-8853

http://real.mtak.hu/25674/

MTMT:2804828; doi:10.1016/j.jmmm.2014.10.146