Complement sensitivity and factor H binding of European Francisella tularensis ssp. holarctica strains in selected animal species
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Archívum: MTA Könyvtár
Gyűjtemény: Status = Published
Type = Article
Cím:
Complement sensitivity and factor H binding of European Francisella tularensis ssp. holarctica strains in selected animal species
Létrehozó:
Kreizinger, Zsuzsa
Bhide, Mangesh
Bencurova, Elena
Dolinska, Saskia
Gyuranecz, Miklós
Dátum:
2015
Téma:
SV Veterinary science / állatorvostudomány
Tartalmi leírás:
Francisella tularensis
is a Gram%negative bacterium, the causative agent
of the
19
zoonotic disease tularaemia. The bacterium has deve
loped several extracellular and
20
intracellular strategies to evade the hosts? innate
and adaptive immune responses. The aims of
21
the study were to examine complement sensitivity of
wild and attenuated
F. tularensis
ssp.
22
holarctica
strains in animal hosts of distinct sensitivity to
the bacterium, to compare the
23
complement evading ability of wild strains of diffe
rent phylogeographic background, and to
24
examine the role of factor H in the host%pathogen i
nteractions. Complement sensitivity assays
25
were carried out on various
F. tularensis
ssp.
holarctica
wild strains and on the attenuated
26
live vaccine strain (LVS) with the sera of the high
ly sensitive house mouse (
Mus musculus
),
27
moderately sensitive European brown hare (
Lepus europaeus
) and the relatively resistant
28
cattle (
Bos taurus
). Specific binding of complement regulator factor
H to bacterial membrane
29
proteins was examined by Western blot assays. All w
ild strains interacted with the hosts?
30
complement system and showed no significant differe
nces in their survivability. The
31
attenuated LVS was resistant to serum killing in mo
use, but was lysed in the sera of hare and
32
cattle. Direct binding of factor H to
F. tularensis
membrane proteins was not detected.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Kreizinger, Zsuzsa and Bhide, Mangesh and Bencurova, Elena and Dolinska, Saskia and Gyuranecz, Miklós (2015) Complement sensitivity and factor H binding of European Francisella tularensis ssp. holarctica strains in selected animal species. ACTA VETERINARIA HUNGARICA, 63 (3). AVH 49/2015. ISSN 0236-6290
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