CD8+/CD103+ tissue-resident memory T cells display substantial functional plasticity and fine-tune their phenotype to meet local needs
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Tartalom: http://real.mtak.hu/25488/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Submitted


Type = Article
Cím:
CD8+/CD103+ tissue-resident memory T cells display substantial functional plasticity and fine-tune their phenotype to meet local needs
Létrehozó:
Lupsa, Nikolett
Érsek, Barbara
Pócza, Péter
Sarzsinszky, Eszter
Toth, Anett
Bagita, Bence
Bencsik, András
Hegyesi, Hargita
Matolcsy, András
Buzás, Edit Irén
Pós, Zoltán
Dátum:
2015
Téma:
Q1 Science (General) / természettudomány általában
R1 Medicine (General) / orvostudomány általában
Tartalmi leírás:
n this study we sought a better understanding of t
he unique phenotypic plasticity displayed
by CD8+/CD103+ tissue-resident memory T cells (Trms
) in distinct tissue environments. Murine Trm
cells were isolated from distinct tissues by automa
ted tissue dissociation and magnetic sorting.
Distinctive features of the Trm phenotype in distin
ct tissues were described by microarray gene
expression profiling, Q-PCR, UPLC-MS/MS, and flow c
ytometry.
We found that CD8+ small intestinal Trms frequently
exhibit an effector-like phenotype,
express various chemokines, granzymes A/B, show evi
dence of degranulation, intense protein
synthesis and sustained clonal expansion. In contra
st, lung-resident Trms typically express
lymphotoxins
?/?,
but not granzymes or markers of degranulation, and
rarely divide due to G2/M
arrest. Finally, CD8+ CD103+ T cells in the liver,
a tolerogenic environment for CD8+ T cells, are
mostly dormant, but often positive for CXCR4, a rec
eptor of the liver-released chemokine SDF-1. We
also found, however, that subtle phenotypic changes
affect non-resident CD8+ T effector (Teff) cells
infiltrating the same tissues, too. Although far le
ss pronounced, these changes were often analogous
to those observed in Trm cells.
These data suggest that Trm cells display a unique
phenotypic plasticity and adapt to varying
environmental conditions by multiple, although not
exclusively Trm-restricted mechanisms.
Típus:
Article
NonPeerReviewed
Formátum:
text
Azonosító:
Lupsa, Nikolett and Érsek, Barbara and Pócza, Péter and Sarzsinszky, Eszter and Toth, Anett and Bagita, Bence and Bencsik, András and Hegyesi, Hargita and Matolcsy, András and Buzás, Edit Irén and Pós, Zoltán (2015) CD8+/CD103+ tissue-resident memory T cells display substantial functional plasticity and fine-tune their phenotype to meet local needs. Journal of Molecular Cell Biology. (Submitted)
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