The impact of left prefrontal repetitive transcranial magnetic stimulation on depression in Parkinson's disease : a randomized, double-blind, placebo-controlled study
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Tartalom: http://real.mtak.hu/24160/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
The impact of left prefrontal repetitive transcranial magnetic stimulation on depression in Parkinson's disease : a randomized, double-blind, placebo-controlled study
Létrehozó:
Pál, Endre
Nagy, Ferenc
Aschermann, Zsuzsanna
Balázs, Éva
Kovács, Norbert
Dátum:
2010
Téma:
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
Tartalmi leírás:
Based on several open-label and case studies, repetitive
transcranial magnetic stimulation (rTMS) seems to have an
antidepressive effect on patients with Parkinson's disease (PD).
However, this hypothesis requires further confirmation.
We conducted a randomized, double-blind placebo-controlled study
to evaluate the effect of rTMS over the left dorsolateral
prefrontal cortex (DLPFC) on depression and various motor and
non-motor features of PD.
Twenty-two PD patients with mild or moderate depressive episodes
were assigned into two groups, one receiving real-rTMS (90% of
resting motor threshold, 5 Hz, 600 pulses-a-day for 10 days)
over the left DLPFC, and another group receiving sham-rTMS. An
investigator blinded to the treatment performed three video-
taped examinations on each patient: before stimulation
(baseline), 1 day (short-term) and 30 days after treatment-
session ended (long-term effect). MMSE, UPDRS, Hoehn-Yahr,
Epworth Sleepiness, Visual Analogue and Montgomery-Asberg
Depression Rating Scales (MADRS), Beck Depression Inventory
(BDI), and Trail making and Stroop tests were applied.
In the actively treated group, not only depression rating scales
showed significant improvement 30 days after treatment ended
(BDI by 44.4% and MADRS by 26.1%), but also the accuracy of
Stroop test (by 16%). We could also demonstrate an insignificant
improvement in UPDRS-III by 7.5 points (31.9%, p=0.06). In the
sham-treated group none of the examined tests and scales
improved significantly after sham stimulation.
Our study demonstrated the beneficial effect of the left DLPFC
rTMS on depression in PD lasting at least 30 days after
treatment. However, this result should be confirmed in patients
with severe depression by further clinical trials.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Pál, Endre and Nagy, Ferenc and Aschermann, Zsuzsanna and Balázs, Éva and Kovács, Norbert (2010) The impact of left prefrontal repetitive transcranial magnetic stimulation on depression in Parkinson's disease : a randomized, double-blind, placebo-controlled study. MOVEMENT DISORDERS, 25 (14). pp. 2311-2317. ISSN 0885-3185
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