| Tartalom: |
http://real.mtak.hu/24150/ |
| Archívum: |
MTA Könyvtár |
| Gyűjtemény: |
Status = Published
Type = Article
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| Cím: |
H-MRS experiences after bilateral DBS of the STN in Parkinson's disease
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| Létrehozó: |
Llumiguano, C.
Kovács, Norbert
Usprung, Z.
Schwarcz, Attila
Dóczi, Tamás Péter
Balás, István
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| Dátum: |
2008
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| Téma: |
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
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| Tartalmi leírás: |
The objective of this study was to evaluate the changes in the
concentrations of certain brain metabolites in 13 patients with
Parkinson's disease before and after bilateral subthalamic nucleus (STN
DBS). The N-acetylaspartate (NAA)/choline (Chol), NAA/creatine (Cr),
Chol/Cr ratios were determined by single voxel Proton magnetic
resonance spectroscopy (H-1-MRS) studies on 1.0T unit using short TE
stimulated echo acquisition mode (STEAM) sequence. Spectra were
obtained from the right and left globus pallidus, and left fronto-basal
cortex. The patients were also assessed according to the UPDRS part
III, in the "medication-on and off" conditions. Conclusions: after STN
DBS cortical NAA/Cho, NAA/Cr ratios increased significantly, which were
highly correlated with the significant improvements of the UPDRS
scores. (c) 2007 Elsevier Ltd. All rights reserved.
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| Típus: |
Article
PeerReviewed
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| Formátum: |
text
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| Azonosító: |
Llumiguano, C. and Kovács, Norbert and Usprung, Z. and Schwarcz, Attila and Dóczi, Tamás Péter and Balás, István (2008) H-MRS experiences after bilateral DBS of the STN in Parkinson's disease. Parkinsonism and Related Disorders, 14 (3). pp. 229-232. ISSN 1353-8020
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