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ABCG2 Is a Selectable Marker for Enhanced Multilineage Differentiation Potential in Periodontal Ligament Stem Cells.

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Tartalom: http://real.mtak.hu/24063/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
ABCG2 Is a Selectable Marker for Enhanced Multilineage Differentiation Potential in Periodontal Ligament Stem Cells.
Létrehozó:
Szepesi, Áron
Matula, Zsolt
Szigeti, Anna
Várady, György
Szabo, G.
Uher, Ferenc
Sarkadi, Balázs
Német, Katalin
Dátum:
2015
Téma:
QR Microbiology / mikrobiológia
Tartalmi leírás:
Periodontal ligament stem cells (PDLSCs) provide an important source for tissue regeneration and may become especially useful in the formation of osteogenic seeds. PDLSCs can be cultured, expanded, and differentiated in vitro; thus, they may be applied in the long-term treatment of the defects in the dental regions. Here we studied numerous potential markers allowing the selection of human PDLSCs with a maximum differentiation potential. We followed the expression of the ATP-binding cassette subfamily G member 2 (ABCG2) membrane transporter protein and isolated ABCG2-expressing cells by using a monoclonal antibody, recognizing the transporter at the cell surface in intact cells. The expression of the ABCG2 protein, corresponding to the so-called side-population phenotype in various tissue-derived stem cells, was found to be a useful marker for the selection of PDLSCs with enhanced osteogenic, chondrogenic, and adipogenic differentiation. These findings may have important applications in achieving efficient dental tissue regeneration by using stem cells from extracted teeth.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Szepesi, Áron and Matula, Zsolt and Szigeti, Anna and Várady, György and Szabo, G. and Uher, Ferenc and Sarkadi, Balázs and Német, Katalin (2015) ABCG2 Is a Selectable Marker for Enhanced Multilineage Differentiation Potential in Periodontal Ligament Stem Cells. STEM CELLS AND DEVELOPMENT, 24 (2). pp. 244-252. ISSN 1547-3287
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