Non-adenosine Nucleoside Inosine, Guanosine and Uridine as Promising Antiepileptic Drugs : a Summary of Current Literature
  • Metaadatok
Tartalom: http://real.mtak.hu/24015/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published



Type = Article
Cím:
Non-adenosine Nucleoside Inosine, Guanosine and Uridine as Promising Antiepileptic Drugs : a Summary of Current Literature
Létrehozó:
Kovács, Zsolt
Kékesi, Katalin A.
Juhász, Gábor
Barna, János
Héja, László
Lakatos, Renáta
Dobolyi, Arpád
Dátum:
2015
Téma:
Q1 Science (General) / természettudomány általában
QP Physiology / élettan
R1 Medicine (General) / orvostudomány általában
Tartalmi leírás:
Adenosine (Ado) and some non-adenosine (non-Ado) nucleosides including inosine (Ino), guanosine (Guo) and uridine (Urd) are modulatory molecules in the central nervous system (CNS), regulating different physiological and pathophysiological processes in the brain such as sleep and epilepsy. Indeed, different drugs effective on adenosinergic system (e.g., Ado metabolism inhibitors, agonists and antagonists of Ado receptors) are being used in drug development for the treatment of epileptic disorders. Although (i) endogenous Ino, Guo and Urd showed anticonvulsant/antiepileptic effects (e.g., in quinolinic acid - induced seizures and in different epilepsy models such as hippocampal kindling models), and (ii) there is need to generate new and more effective antiepileptic drugs for the treatment of drug-resistant epilepsies, our knowledge about antiepileptic influence of non-Ado nucleosides is far from complete. Thus, in this review article, we give a short summary of anticonvulsant/antiepileptic effects and mechanisms evoked by Ino, Guo, and Urd. Finally, we discuss some non-Ado nucleoside derivatives and their structures, which may be candidates as potential antiepileptic agents.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Kovács, Zsolt and Kékesi, Katalin A. and Juhász, Gábor and Barna, János and Héja, László and Lakatos, Renáta and Dobolyi, Arpád (2015) Non-adenosine Nucleoside Inosine, Guanosine and Uridine as Promising Antiepileptic Drugs : a Summary of Current Literature. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 14 (13). pp. 1033-1042. ISSN 1389-5575
Kapcsolat: