| Tartalom: |
http://www.sciencedirect.com/science/article/pii/S0009261... |
| Archívum: |
MTA Könyvtár |
| Gyűjtemény: |
Status = Published
Type = Article
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| Cím: |
A theoretical study of the stability of disulfide bridges in various ?-sheet structures of protein segment models
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| Létrehozó: |
Galant, Natalie J.
Song, Heeyeon Cheryl
Jákli, Imre
Viskolcz, Béla
Csizmadia, G. Imre
Jensen, Svend J. Knak
Perczel, András
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| Dátum: |
2014-02
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| Téma: |
QD Chemistry / kémia
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| Tartalmi leírás: |
Electron structure calculations are used to explore stabilization effects of disulfide bridges in a (Ala?Cys?Ala?Cys?Ala)2 ?-sheet model both in the parallel and the anti-parallel (103142 and 143102) arrangements. Stabilities were calculated using a redox reaction involving a weak oxidizing agent (1,4-benzoquinone). The results show that both inter- and intra-strand disulfide SS-bridges stabilize the ?-sheet backbone fold. However, inter-strand SS-bridges give more stability than their intra-strand counterparts. For both single and double disulfide linked conformations, stabilization was larger for the parallel than for the anti-parallel ?-sheet arrangements.
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| Típus: |
Article
NonPeerReviewed
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| Formátum: |
text
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| Azonosító: |
Galant, Natalie J. and Song, Heeyeon Cheryl and Jákli, Imre and Viskolcz, Béla and Csizmadia, G. Imre and Jensen, Svend J. Knak and Perczel, András (2014) A theoretical study of the stability of disulfide bridges in various ?-sheet structures of protein segment models. CHEMICAL PHYSICS LETTERS, 593. pp. 48-54. ISSN 0009-2614
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