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Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis. |
Tartalom: | http://dx.doi.org/10.1038/jid.2013.18 |
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Archívum: | MTA Könyvtár |
Gyűjtemény: |
Status = Published
Type = Article |
Cím: |
Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis.
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Létrehozó: |
Samuelov, L.
Sprecher, E.
Sugawara, K.
Singh, S.K.
Tobin, D.J.
Bíró, Tamás
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Dátum: |
2013
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Téma: |
RL Dermatology / bőrgyógyászat
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Tartalmi leírás: |
P-cadherin serves as a major topobiological cue in mammalian epithelium. In human hair follicles (HFs), it is prominently expressed in the inner hair matrix that harbors the HF pigmentary unit. However, the role of P-cadherin in normal human pigmentation remains unknown. Since patients with mutations in the gene that encodes P-cadherin show hypotrichosis and fair hair, we explored the hypothesis that P-cadherin may control HF pigmentation. When P-cadherin was silenced in melanogenically active organ-cultured human scalp HFs, this significantly reduced HF melanogenesis and tyrosinase activity as well as gene and/or protein expression of gp100, stem cell factor, c-Kit, and microphthalmia-associated transcription factor (MITF), both in situ and in isolated human HF melanocytes. Instead, epidermal pigmentation was unaffected by P-cadherin knockdown in organ-cultured human skin. In hair matrix keratinocytes, P-cadherin silencing reduced plasma membrane beta-catenin, while glycogen synthase kinase 3 beta (GSK3beta) and phospho-beta-catenin expression were significantly upregulated. This suggests that P-cadherin-GSK3beta/Wnt signaling is required for maintaining expression of MITF to sustain intrafollicular melanogenesis. Thus, P-cadherin-mediated signaling is a melanocyte subtype-specific topobiological regulator of normal human pigmentation, possibly via GSK3beta-mediated canonical Wnt signaling.Journal of Investigative Dermatology accepted article preview online, 18 January 2013; doi:10.1038/jid.2013.18.
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Típus: |
Article
PeerReviewed
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Formátum: |
text
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Azonosító: |
Samuelov, L. and Sprecher, E. and Sugawara, K. and Singh, S.K. and Tobin, D.J. and Bíró, Tamás (2013) Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133 (6). pp. 1591-1600. ISSN 0022-202X
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