| Tartalom: |
http://linkinghub.elsevier.com/retrieve/pii/S001457931300... |
| Archívum: |
MTA Könyvtár |
| Gyűjtemény: |
Status = Published
Type = Article
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| Cím: |
Transient receptor potential vanilloid-2 mediates the effects of transient heat shock on endocytosis of human monocyte-derived dendritic cells
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| Létrehozó: |
Szöllősi, Attila
Oláh, Attila
Tóth, Balázs István
Papp, Ferenc
Czifra, Gabriella
Panyi, György
Bíró, Tamás
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| Dátum: |
2013
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| Téma: |
QH3015 Molecular biology / molekuláris biológia
R1 Medicine (General) / orvostudomány általában
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| Tartalmi leírás: |
Our goal was to investigate the effect of heat shock on human monocyte-derived dendritic cells (DCs) and to dissect the role of thermosensitive transient receptor potential (TRP) channels in the process. We provide evidence that a short heat shock challenge (43 degrees C) decreased the endocytotic activity of the DCs and that this effect could be alleviated by the RNAi-mediated knockdown of TRPV2 but, importantly, not by the pharmacological (antagonists) or molecular (RNAi) suppression of TRPV1 and TRPV4 activities/levels. Likewise, the heat shock-induced robust membrane currents were selectively and markedly inhibited by TRPV2 "silencing" whereas modulation of TRPV1 and TRPV4 activities, again, had no effect. These intriguing data introduce TRPV2-coupled signaling as a key player in mediating the cellular actions of heat shock on DCs.
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| Típus: |
Article
PeerReviewed
info:eu-repo/semantics/article
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| Formátum: |
text
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| Azonosító: |
Szöllősi, Attila and Oláh, Attila and Tóth, Balázs István and Papp, Ferenc and Czifra, Gabriella and Panyi, György and Bíró, Tamás (2013) Transient receptor potential vanilloid-2 mediates the effects of transient heat shock on endocytosis of human monocyte-derived dendritic cells. FEBS LETTERS, 587 (9). pp. 1440-1445. ISSN 0014-5793
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| Kapcsolat: |
FP7-REGPOT-2008-1/229920
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