A wider view on gastric erosion: detailed evaluation of complex somatic and behavioral changes in rats treated with indomethacin at gastric ulcerogenic dose.
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Tartalom: http://real.mtak.hu/20720/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
A wider view on gastric erosion: detailed evaluation of complex somatic and behavioral changes in rats treated with indomethacin at gastric ulcerogenic dose.
Létrehozó:
Filaretova, L. P.
Bagaeva, T. R.
Morozova, O. Y.
Zelena, Dóra
Dátum:
2014
Téma:
R1 Medicine (General) / orvostudomány általában
Tartalmi leírás:
Objective. Gastric erosion is widespread side effect of nonsteroidal anti-inflammatory drugs. To examine the complexity of the brain-gut axis regulation, indomethacin-induced gastric erosion formation was studied in connection with somatic and behavioral changes.Methods. During a constant telemetric recording of heart rate, body temperature, and locomotion of male rats we examined the effects of 24 h fasting, indomethacin (35 mg/kg s.c.) injection, and refeeding at 4 h. Behavior was analyzed on elevated plus maze (EPM) at 24 h and somatic changes at 72 h.Results. Gastric erosion developed 4 h after indomethacin injection, healed 72 h later contrasted by large injury in the small intestine. As classical signs of chronic stress, body and thymus weight were reduced while adrenal weight was enhanced 72 h after indomethacin injection. Fasting by itself changed all telemetrically recorded parameters with most prominent decrease in heart rate. Indomethacin induced similar diminishing effects with earliest and strongest temperature decrease. As a sign of more anxious phenotype locomotion reducing effect of indomethacin injection was detected on EPM. The EPM-induced temperature elevation was missing in indomethacin-treated animals.Conclusions. Fasting by itself induce somatic changes, which can make the animals more vulnerable to ulcerogenic stimuli. Development of indomethacin-induced gastrointestinal lesions happened in parallel with disturbances of heart rate, core body temperature, and chronic stress-like somatic changes as well as anxiety-like behavior. We have to be more aware of the existence of the brain-gut axis and should study changes in the whole body rather than focusing on a specific organ. KEYWORDS: indomethacin, gastrointestinal injury, telemetry, heart rate, body temperature, locomotion, somatic parameters, elevated plus maze.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Filaretova, L. P. and Bagaeva, T. R. and Morozova, O. Y. and Zelena, Dóra (2014) A wider view on gastric erosion: detailed evaluation of complex somatic and behavioral changes in rats treated with indomethacin at gastric ulcerogenic dose. Endocrine Regulations, 48 (4). pp. 163-172. ISSN 1210-0668
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