Quantitative phenotyping of chromatic dysfunction in best macular dystrophy
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Tartalom: http://archopht.jamanetwork.com/article.aspx?articleid=41...
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Quantitative phenotyping of chromatic dysfunction in best macular dystrophy
Létrehozó:
Campos, Sónia H.
Forjaz, Vasco
Kozák, Lajos R.
Silva, Eduardo
Castelo-Branco, Miguel
Dátum:
2005-07
Téma:
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
RE Ophthalmology / szemészet
Tartalmi leírás:
OBJECTIVES
To quantify chromatic dysfunction in Best disease to reassess the classic categorization of macular chromatic damage and to investigate psychophysical and clinical correlations.
METHODS
Color-contrast discrimination was measured using 2 different psychophysical strategies in age-matched control (n = 41) and patient (n = 34) eyes. The first strategy measured performance along 3 main confusion lines (testing cone function), and the second evaluated discrimination ellipses (modified Cambridge Color Test). The main outcome measures were chromatic discrimination variables (confusion line length, ellipse length, angle, and axis ratio) and visual acuity (VA).
RESULTS
Significant loss of performance was seen in all color axes in our patients, and it increased monotonically with staging, becoming significant in Fishman stages 2 and 3. The classically assumed preferential type I red-green deficit was true only for stage 4. Substantial chromatic dysfunction occurred even with relatively preserved VA despite that negative correlations between all test variables and VA reached statistical significance. Partial correlation analysis showed that protan/deutan loss was related to VA independent of tritan loss. Statistically significant positive correlations were also found between lesion size and chromatic dysfunction.
CONCLUSIONS
Chromatic discrimination is often impaired in Best disease, even when VA is still spared. Our quantitative psychophysical approach shows that the classic categorization as a type I red-green deficit is valid only for disease stage 4.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Campos, Sónia H. and Forjaz, Vasco and Kozák, Lajos R. and Silva, Eduardo and Castelo-Branco, Miguel (2005) Quantitative phenotyping of chromatic dysfunction in best macular dystrophy. Archives of ophthalmology, 123 (7). pp. 944-9. ISSN 0003-9950
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