| Tartalmi leírás: |
Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Candida albicans remains the main cause, the incidence of emerging Candida species, such as C. parapsilosis is increasing. It has been postulated that C. parapsilosis clinical isolates result from a recent global expansion of a virulent clone. However, the availability of a single genome for this species has so far prevented testing this hypothesis at genomic scales. We present here the sequence of three additional strains from clinical and environmental samples. Our analyses reveal unexpected patterns of genomic variation, shared among distant strains, that argue against the clonal expansion hypothesis. All strains carry independent expansions involving an arsenite transporter homolog, pointing to the existence of directional selection in the environment, and independent origins of the two clinical isolates. Furthermore, we report the first evidence for the existence of recombination in this species. Altogether, our results shed new light onto the dynamics of genome evolution in C. parapsilosis.
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| Azonosító: |
Pryszcz, Leszek P and Németh, Tibor and Gácser, Attila and Gabaldón, Toni (2013) Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis. GENOME BIOLOGY AND EVOLUTION, 5 (12). pp. 2382-92. ISSN 1759-6653
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