Turning gold into 'junk': transposable elements utilize central proteins of cellular networks
  • Metaadatok
Tartalom: http://nar.oxfordjournals.org/content/41/5.toc
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Turning gold into 'junk': transposable elements utilize central proteins of cellular networks
Létrehozó:
Abrusán, György
Szilágyi, András
Zhang, Yang
Papp, Balázs
Dátum:
2013
Téma:
QH3011 Biochemistry / biokémia
QH3015 Molecular biology / molekuláris biológia
Tartalmi leírás:
The numerous discovered cases of domesticated
transposable element (TE) proteins led to the recognition
that TEs are a significant source of evolutionary
innovation. However, much less is known about
the reverse process, whether and to what degree
the evolution of TEs is influenced by the genome
of their hosts. We addressed this issue by searching
for cases of incorporation of host genes into the
sequence of TEs and examined the systems-level
properties of these genes using the Saccharomyces
cerevisiae and Drosophila melanogaster genomes.
We identified 51 cases where the evolutionary
scenario was the incorporation of a host gene
fragment into a TE consensus sequence, and we
show that both the yeast and fly homologues of
the incorporated protein sequences have central
positions in the cellular networks. An analysis of selective
pressure (Ka/Ks ratio) detected significant
selection in 37% of the cases. Recent research on
retrovirus-host interactions shows that virus
proteins preferentially target hubs of the host interaction
networks enabling them to take over the host
cell using only a few proteins. We propose that TEs
face a similar evolutionary pressure to evolve proteins
with high interacting capacities and take some
of the necessary protein domains directly from their
hosts.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Abrusán, György and Szilágyi, András and Zhang, Yang and Papp, Balázs (2013) Turning gold into 'junk': transposable elements utilize central proteins of cellular networks. Nucleic Acids Research, 41 (5). pp. 3190-3200. ISSN 0305-1048 (print), 1362-4962 (online)
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