| Létrehozó: |
Simons, Sami O.
Kristiansen, Jette E.
Hajós, György
Laan, Tridia van der
Molnár, József
Boeree, Martin J.
Ingen, Jakko van
Christensen, Jřrn B.
Viveiros, Miguel
Riedl, Zsuzsanna
Amaral, Leonard
Soolingen, Dick van
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| Tartalmi leírás: |
Organosilicon compounds are efflux pump inhibitors with potency as an antituberculosis drug. Of the organisilicon compounds tested, SILA 421 has been shown to have a highest potency as an antituberculosis drug (1). It shares the common pathways for antimycobacterial killing with other efflux pump inhibitors: it revealed direct in vitro activity against M. tuberculosis (1), it has been shown to modify resistance by inhibiting mdr-1 efflux pumps and has shown to enhance killing of M. tuberculosis by macrophages (1).
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| Azonosító: |
Simons, Sami O. and Kristiansen, Jette E. and Hajós, György and Laan, Tridia van der and Molnár, József and Boeree, Martin J. and Ingen, Jakko van and Christensen, Jřrn B. and Viveiros, Miguel and Riedl, Zsuzsanna and Amaral, Leonard and Soolingen, Dick van (2013) Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis. International Journal of Antimicrobial Agents, 41 (5). pp. 488-489. ISSN 0924-8579
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