Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster
  • Metaadatok
Tartalom: http://www.pnas.org/content/106/12/4805.long
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster
Létrehozó:
Márkus, Róbert
Laurinyecz, Barbara
Kurucz, Éva
Honti, Viktor
Bajusz, Izabella
Sipos, Botond
Somogyi, Kálmán
Kronhamn, Jesper
Hultmark, Dan
Andó, István
Dátum:
2009
Téma:
QR180 Immunology / immunológia
Tartalmi leírás:
The blood cells, or hemocytes, in Drosophila participate in the immune response through the production of antimicrobial peptides, the phagocytosis of bacteria, and the encapsulation of larger foreign particles such as parasitic eggs; these immune reactions are mediated by phylogenetically conserved mechanisms. The encapsulation reaction is analogous to the formation of granuloma in vertebrates, and is mediated by large specialized cells, the lamellocytes. The origin of the lamellocytes has not been formally established, although it has been suggested that they are derived from the lymph gland, which is generally considered to be the main hematopoietic organ in the Drosophila larva. However, it was recently observed that a subepidermal population of sessile blood cells is released into the circulation in response to a parasitoid wasp infection. We set out to analyze this phenomenon systematically. As a result, we define the sessile hemocytes as a novel hematopoietic compartment, and the main source of lamellocytes.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Márkus, Róbert and Laurinyecz, Barbara and Kurucz, Éva and Honti, Viktor and Bajusz, Izabella and Sipos, Botond and Somogyi, Kálmán and Kronhamn, Jesper and Hultmark, Dan and Andó, István (2009) Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America, 106 (12). pp. 4805-4809. ISSN 1091-6490
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