| Tartalom: |
http://www.sciencedirect.com/science/article/pii/S0944711... |
| Archívum: |
MTA Könyvtár |
| Gyűjtemény: |
Status = Published
Type = Article
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| Cím: |
20-Hydroxyecdysone increases fiber size in a muscle-specific fashion in rat
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| Létrehozó: |
Tóth, Noémi
Szabó, András
Kacsala, Péter
Héger, Júlia
Zádor, Ernő
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| Dátum: |
2008
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| Téma: |
R1 Medicine (General) / orvostudomány általában
RM Therapeutics. Pharmacology / terápia, gyógyszertan
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| Tartalmi leírás: |
20-Hydroxyecdysone (20E) is an ecdysteroid hormone that regulates moulting in insects. Interestingly, 20E is also
found most abundantly in plant species and has anabolic effects in vertebrates, i.e. increasing muscle size without
androgen influence. The effect of 20E on slow and fast fiber types of skeletal muscle has not been reported yet. Here we
present that 20E affects the size (cross-sectional area, CSA) of the different fiber types in a muscle-specific manner. The
effect on fiber size was modified by the distance from the site of the treatment and the presence of a regenerating soleus
muscle in the animal. Besides the fiber size, 20E also increased the myonuclear number in the fibers of normal and
regenerating muscles, suggesting the activation of satellite cells. According to our results 20E may provide an
alternative for substitution of anabolic?androgenic steroids in therapeutic treatments against muscle atrophy.
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| Típus: |
Article
PeerReviewed
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| Formátum: |
text
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| Azonosító: |
Tóth, Noémi and Szabó, András and Kacsala, Péter and Héger, Júlia and Zádor, Ernő (2008) 20-Hydroxyecdysone increases fiber size in a muscle-specific fashion in rat. PHYTOMEDICINE, 15 (9). pp. 691-698. ISSN 0944-7113
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