| Tartalmi leírás: |
Mitochondrial toxins are a special group of toxicants with nervous system ef TRACT -
fects. The resulting nervous system damage could be detected and followed-up by means of
functional biomarkers but these still have to be worked out. In this work, adult male Wistar
rats were anesthetized with urethane, the left hemisphere was exposed, and a silver recording
electrode was placed on the projection area of the whiskers. The whisker pad was stimulated
with electric square pulses and the cortical response was recorded. The intensity of the stimulus
was varied between 25% and 100% (just supramaximal), and its frequency, between 1 and 10
Hz. Control records were taken, then one of the agents (3-nitrporopionic acid, a mitochondrial
toxin of microfungal origin: 20 mg/kg b.w.; or manganese, a heavy metal: 50 mg/kg b.w. in
chloride form) was injected ip. and further records were taken. Both agents had an effect on
the latency, but on the amplitude, only Mn. Of the relationships between stimulation settings
and evoked potential parameters, frequency dependence of latency had the clearest alteration
on application of Mn or 3-NP. Such effects may have the potency to be developed to functional
biomarkers, applicable in practical toxicology or in animal research.
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| Azonosító: |
Takács, Sz. and Bankó, S. and Papp, András (2009) Altered stimulus frequency and intensity dependence of the somatosensory evoked potential in rats after acute application of two mitochondrial toxins. ACTA BIOLOGICA SZEGEDIENSIS, 53 (3). pp. 99-103. ISSN 1588-385X
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