| Tartalom: |
http://real.mtak.hu/6361/ |
| Archívum: |
MTA Könyvtár |
| Gyűjtemény: |
Status = Published
Type = Article
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| Cím: |
The N-terminal 303 amino acids of the human cytomegalovirus envelope glycoprotein B (UL55) and the exon 4 region of the major immediate early protein 1 (UL123) induce a cytotoxic T-cell response
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| Létrehozó: |
Berencsi, K.
Gönczöl, Éva
Endrész, Valéria
Gyulai, Zsófia
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| Kiadó: |
Elsevier
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| Dátum: |
1996
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| Téma: |
QR180 Immunology / immunológia
RZ Other systems of medicine / orvostudomány egyéb területei
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| Tartalmi leírás: |
We reported earlier that an adenovirus (Ad) recombinant expressing the full-length human cytomegalovirus (HCMV) glycoprotein B (gB) gene induces gB-specific cytotoxic T lymphocyte (CTL) responses in CBA (H-2(k)) mice (Berencsi et al., J. Gen. Virol. 74, 257-2512, 1993). Here we show that mice immunized with Ad recombinant viruses expressing truncated forms of the gB gene containing the first 700 (Ad-700), 465 (Ad-465) or 303 (Ad-303) amino acids of gB or an Ad construct containing exon 4 (E4) of the HCMV immediate early 1 (IE1) gene (Ad-IE1 (E4)) demonstrate HCMV-specific CTL responses, These data suggest the importance of the first 303 amino acids of the gB polypeptide and the IE1 E4 product in designing a vaccine to induce anti-HCMV CTL responses.
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| Típus: |
Article
PeerReviewed
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| Formátum: |
text
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| Azonosító: |
Berencsi, K. and Gönczöl, Éva and Endrész, Valéria and Gyulai, Zsófia (1996) The N-terminal 303 amino acids of the human cytomegalovirus envelope glycoprotein B (UL55) and the exon 4 region of the major immediate early protein 1 (UL123) induce a cytotoxic T-cell response. VACCINE, 14 (5). pp. 369-374. ISSN 0264-410X
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