Zonula occludens-1, occludin, and E-cadherin protein expression in biliary tract cancers
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Tartalom: http://real.mtak.hu/6184/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Zonula occludens-1, occludin, and E-cadherin protein expression in biliary tract cancers
Létrehozó:
Németh, Zsuzsanna
Szász, Attila Marcell
Somorácz, Áron
Tátrai, Péter
Németh, J.
Győrffy, Hajnalka
Szijártó, Attila
Kupcsulik, Péter
Kiss, András
Schaff, Zsuzsa
Kiadó:
Springer
Dátum:
2009
Téma:
RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
RZ Other systems of medicine / orvostudomány egyéb területei
Tartalmi leírás:
The incidence of cholangiocarcinomas originating from intrahepatic and extrahepatic bile ducts, as well as of gallbladder carcinoma is increasing worldwide. The malignant transformation of biliary epithelia involves profound alterations of proteins in the intercellular junctions, among others zonula occludens-1 (ZO-1), occludin, and E-cadherin. Each plays important role in the maintenance of epithelial cell polarity and regulation of cell growth and differentiation. Our aim was to investigate ZO-1, occludin, and E-cadherin immunohistochemical reactions in tissue microarray blocks containing 57 normal and 62 neoplastic biliary tract samples. We demonstrated that the tight junction components ZO-1, occludin, and E-cadherin are downregulated in carcinomas arising from various compartments of the biliary tract (normal intrahepatic and extrahepatic bile ducts, gallbladder) as compared with their normal sites of origin. These results were confirmed by discriminant analysis yielding clear separation of the three normal sample groups from carcinomas in the corresponding locations.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Németh, Zsuzsanna and Szász, Attila Marcell and Somorácz, Áron and Tátrai, Péter and Németh, J. and Győrffy, Hajnalka and Szijártó, Attila and Kupcsulik, Péter and Kiss, András and Schaff, Zsuzsa (2009) Zonula occludens-1, occludin, and E-cadherin protein expression in biliary tract cancers. Pathology and Oncology Research, 15 (3). pp. 533-539. ISSN 1219-4956
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