| Tartalom: |
http://real.mtak.hu/5274/ |
| Archívum: |
MTA Könyvtár |
| Gyűjtemény: |
Status = Published
Type = Article
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| Cím: |
The altered expression of syndecan 4 in the uninvolved skin of venous leg ulcer patients may predispose to venous leg ulcer
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| Létrehozó: |
Nagy, Nikoletta
Németh, István Balázs
Szabad, Gábor
Szolnoky, Győző
Belső, Nóra
Csörgő Sándorné Bata, Zsuzsanna
Dobozy, Attila
Kemény, Lajos
Széll, Márta
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| Kiadó: |
Wiley-Blackwell
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| Dátum: |
2008
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| Téma: |
RD Surgery / sebészet
RL Dermatology / bőrgyógyászat
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| Tartalmi leírás: |
Syndecan 4 (SDC4), a heparan sulfate proteoglycan, and neuropilin 1
(NRP1), a transmembrane receptor, are both involved in normal wound
healing, but little is known about their possible role in venous leg
ulcer pathogenesis. We aimed to investigate whether there are any
expression abnormalities and/or gene polymorphisms of SDC4 and NRP1
associated with venous leg ulcer. SDC4 showed significantly lower mRNA
and protein expression in the uninvolved dermis of venous leg ulcer
patients (n=15) compared with controls (n=15; p=0.0136), while NRP1
showed no expression abnormalities. None of the examined SDC4 and NRP1
polymorphisms showed a difference in their allelic distribution between
leg ulcer patients (n=92) and controls (n=92). We hypothesize that SDC4
may play an essential role not only in the inflammation and tissue
formation phases of normal wound healing, but its expression
abnormalities observed in the uninvolved dermis of venous leg ulcer
patients may contribute to venous leg ulcer development.
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| Típus: |
Article
PeerReviewed
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| Formátum: |
text
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| Azonosító: |
Nagy, Nikoletta and Németh, István Balázs and Szabad, Gábor and Szolnoky, Győző and Belső, Nóra and Csörgő Sándorné Bata, Zsuzsanna and Dobozy, Attila and Kemény, Lajos and Széll, Márta (2008) The altered expression of syndecan 4 in the uninvolved skin of venous leg ulcer patients may predispose to venous leg ulcer. WOUND REPAIR AND REGENERATION, 16 (4). pp. 495-502. ISSN 1067-1927
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