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Effects of intranasal phototherapy on nasal mucosa in patients with allergic rhinitis.

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Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Effects of intranasal phototherapy on nasal mucosa in patients with allergic rhinitis.
Koreck, A.
Szécsényi, Anita
Mórocz, Mónika
Bella, Zsolt
Garaczi, Edina
Raskó, István
Kemény, Lajos
Elsevier Science Publishers B.V.
QC Physics / fizika
QC02 Optics / fénytan
QH3011 Biochemistry / biokémia
QH3015 Molecular biology / molekuláris biológia
QH3020 Biophysics / biofizika
RF Otorhinolaryngology / orr-, fül-, gégészet
RZ Other systems of medicine / orvostudomány egyéb területei
Tartalmi leírás:
Rationale: Rhinophototherapy has been shown to be effective in the treatment of allergic rhinitis. Considering that phototherapy with
ultraviolet light (UV) induces DNA damage, it is of outstanding importance to evaluate the damage and repair process in human nasal
Methods: We have investigated eight patients undergoing intranasal phototherapy using a modified Comet assay technique and by
staining nasal cytology samples for cyclobutane pyrimidine dimers (CPDs), which are UV specific photoproducts.
Results: Immediately after last treatment Comet assay of nasal cytology samples showed a significant increase in DNA damage compared
to baseline. Ten days after the last irradiation a significant decrease in DNA damage was observed compared to data obtained
immediately after finishing the treatment protocol. Difference between baseline and 10 days after last treatment was not statistically significant.
Two months after ending therapy, DNA damage detected by Comet assay in patients treated with intranasal phototherapy was
similar with that of healthy individuals. None of the samples collected before starting intranasal phototherapy stained positive for CPDs.
In all samples collected immediately after last treatment strong positive staining for CPDs was detected. The number of positive cells
significantly decreased 10 days after last treatment, but residual positive staining was present in all the examined samples. This finding
is consistent with data reported in skin samples after UV irradiation. Cytology samples examined two months after ending therapy contained
no CPD positive cells.
Conclusion: Our results suggest that UV damage induced by intranasal phototherapy is efficiently repaired in nasal mucosa.
Koreck, A. and Szécsényi, Anita and Mórocz, Mónika and Bella, Zsolt and Garaczi, Edina and Raskó, István and Kemény, Lajos (2007) Effects of intranasal phototherapy on nasal mucosa in patients with allergic rhinitis. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 89 (2-3). pp. 163-169. ISSN 1011-1344