| Tartalom: |
http://real.mtak.hu/5260/ |
| Archívum: |
MTA Könyvtár |
| Gyűjtemény: |
Status = Published
Type = Article
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| Cím: |
A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions
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| Létrehozó: |
Bodnár, Andrea
Nizsalóczki, E.
Mocsár, G.
Damjanovich, Sándor
Vámosi, György
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| Kiadó: |
Elsevier - North-Holland
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| Dátum: |
2008
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| Téma: |
QH3020 Biophysics / biofizika
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| Tartalmi leírás: |
Interleukin-2 and interleukin-15 (IL-2, IL-15) are key participants in T and NK cell activation and function. Sharing the beta and gamma
receptor subunits results in several common functions: e.g. the promotion of T cell proliferation. On the other hand, due to their distinct alpha
receptor subunits, they also play opposing roles in immune processes such as activation induced cell death and immunological memory. Divergence
of signaling pathways must ensue already at the plasma membrane where the cytokines interact with their receptors. Therefore understanding
molecular details of receptor organization and mapping interactions with other membrane proteins that might influence receptor conformation
and function, are of key importance. Biophysical/advanced microscopic methods (fluorescence resonance energy transfer (FRET), fluorescence
crosscorrelation spectroscopy (FCCS), near-field scanning optical microscopy (NSOM), X-ray crystallography, surface plasmon resonance, NMR
spectroscopy) have been instrumental in clarifying the details of receptor structure and organization from the atomic level to the assembly and
dynamics of supramolecular clusters. In this short review some important contributions shaping our current view of IL-2 and IL-15 receptors are
presented.
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| Típus: |
Article
PeerReviewed
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| Formátum: |
text
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| Azonosító: |
Bodnár, Andrea and Nizsalóczki, E. and Mocsár, G. and Damjanovich, Sándor and Vámosi, György (2008) A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions. IMMUNOLOGY LETTERS, 116. pp. 117-125. ISSN 0165-2478
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