Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material
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Tartalom: http://real.mtak.hu/5148/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material
Létrehozó:
Collingwood, Joanna F.
Chong, Ryan K. K.
Kasama, Takeshi
Cervera-Gontard, Lionel
Dunin-Borkowski, Rafal E.
Perry, George
Pósfai, Mihály
Siedlak, Sandra L.
Simpson, Edward T.
Smith, Mark A.
Dobson, Jon
Kiadó:
IOS Press
Dátum:
2008
Téma:
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
Tartalmi leírás:
Although it has been known for over 50 years that abnormal concentrations of iron are associated with virtually
all neurodegenerative diseases, including Alzheimer?s disease, its origin, nature and role have remained a mystery. Here, we
use high-resolution transmission electron microscopy (HR-TEM), energy dispersive X-ray (EDX) spectroscopy and electron
energy-loss spectroscopy (EELS), electron tomography, and electron diffraction to image and characterize iron-rich plaque
core material ? a hallmark of Alzheimer?s disease pathology ? in three dimensions. In these cores, we unequivocally identify
biogenic magnetite and/or maghemite as the dominant iron compound. Our results provide an indication that abnormal iron
biomineralization processes are likely occurring within the plaque or the surrounding diseased tissue and may play a role in
aberrant peptide aggregation. The size distribution of the magnetite cores implies formation from a ferritin precursor, implicating
a malfunction of the primary iron storage protein in the brain.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Collingwood, Joanna F. and Chong, Ryan K. K. and Kasama, Takeshi and Cervera-Gontard, Lionel and Dunin-Borkowski, Rafal E. and Perry, George and Pósfai, Mihály and Siedlak, Sandra L. and Simpson, Edward T. and Smith, Mark A. and Dobson, Jon (2008) Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material. Journal of Alzheimer's Disease, 14 (2). pp. 235-245. ISSN 1387-2877
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