Deep-brain silicon multielectrodes for simultaneous neural recording and drug delivery.
  • Metaadatok
Tartalom: http://real.mtak.hu/4915/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published



Type = Article
Cím:
Deep-brain silicon multielectrodes for simultaneous neural recording and drug delivery.
Létrehozó:
Pongrácz, Anita
Fekete, Zoltán
Márton, Gergely
BĂ©rczes, Zs.
Ulbert, István
FĂĽrjes, PĂ©ter
Kiadó:
Elsevier
Dátum:
2013
Téma:
QP Physiology / Ă©lettan
R1 Medicine (General) / orvostudomány általában
TK Electrical engineering. Electronics Nuclear engineering / elektrotechnika, elektronika, atomtechnika
Tartalmi leírás:
In this paper, the fabrication method, electrical and fluidic characterization and in vivo testing of the
first deep brain silicon multielectrode with monolithically integrated fluidic channel are presented in
details. Micromachined silicon probes with monolithically integrated microfluidic channels up to 70 mm
length have been realized to perform simultaneous electrical recording and drug delivery in deep brain
regions. The achieved cross-sectional dimension of the microchannels is in the range of 5–30 µm, while
the length of the channel can be even 70 mm long.Fabrication process and integration of the drug delivery
channels and the Pt recording sites are described. Electrical characterization and impedance tuning of the
developed probes are also demonstrated. The functionality of the microfluidic channels is verified and
the hydrodynamic characteristics (flow rate vs. injection pressure) are measured in the case of several
length and cross-sections.Feasibility of our integration concept is proved by locally injected bicuculline in
the cortex and in the thalamical regions of rat brain in vivo, while simultaneously recording the electrical
signals of the stimulated neurons on four different electrical channels.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Pongrácz, Anita and Fekete, Zoltán and Márton, Gergely and Bérczes, Zs. and Ulbert, István and Fürjes, Péter (2013) Deep-brain silicon multielectrodes for simultaneous neural recording and drug delivery. SENSORS AND ACTUATORS B-CHEMICAL, 189. pp. 97-105. ISSN 0925-4005
Kapcsolat:
10.1016/j.snb.2013.01.032
Létrehozó:
info:eu-repo/semantics/openAccess