Pancreatic Autoantibodies Are Associated with Reactivity to Microbial Antibodies, Penetrating Disease Behavior, Perianal Disease, and Extraintestinal Manifestations, But Not with NOD2/CARD15 or TLR4 Genotype in a Hungarian IBD Cohort
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Tartalom: http://dx.doi.org/10.1002/ibd.20778
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Pancreatic Autoantibodies Are Associated with Reactivity to Microbial Antibodies, Penetrating Disease Behavior, Perianal Disease, and Extraintestinal Manifestations, But Not with NOD2/CARD15 or TLR4 Genotype in a Hungarian IBD Cohort
Létrehozó:
Lakatos, Péter László
Altorjay, István
Szamosi, Tamás
Palatka, Károly
Vitalis, Zsuzsanna
Tumpek, Judit
Sipka, Sándor
Udvardy, Miklós
Dinya, Tamás
Lakatos, László
Kovács, Ágota
Molnár, Tamás
Tulassay, Zsolt
Miheller, Pál
Barta, Zsolt
Stocker, Winfried
Papp, János
Veres, Gábor
Papp, Mária
Kiadó:
Lippincott, Williams and Wilkins
Dátum:
2009
Téma:
RC Internal medicine / belgyógyászat
Tartalmi leírás:
Background: Pancreatic autoantibodies (PAB) and goblet cell autoantibodies (GAB) are specific for Crohn's disease (CD) and ulcerative colitis (UC). but the sensitivity alone is low. Conventional antibodies and carbohydrates (glycans) are associated with disease phenotype and may be of diagnostic importance in inflammatory bowel disease (IBD). Our aim was to determine the accuracy of PAB and GAB autoantibodies as well LIS to Study relevant phenotype-serotype associations.
Methods: A Hungarian study cohort of 1092 subjects, including 689 well-characterized, unrelated IBD patients (CD: 579, m/f ratio: 274/305. duration: 7.9 +/- 11.2 years UC: 110 m/f ratio: 53/57, duration: 8.9 +/- 9.8 years), 139 celiac patients, 100 healthy, and 64 non-IBD gastrointestinal controls were investigated. Sera were assayed for PAB-GAB IgA/IgG. anti-Omp. cerevisiae antibodies (ASCA), and anti-glycans. TLR4 and NOD2/CARD15 was tested by polymerase chain reaction / restriction fragment length polymorphism (PCR-RFLP). Detailed clinical phenotypes were determined.
Results: The prevalence of PAB was significantly more frequent in CD (41.1%) versus UC (22.7%). celiac (22.3%), and controls (8% and 4.6%, P < 0.01 for each). while GAB detection was poor in all groups except UC (15.4%). In CD the combination of PAB and/or anti-glycans/ASCA increased the sensitivity to 72% and 59%, respectively, for isolated colonic disease. PAB was associated to gylcans (odds ratio [OR] 1.74, P = 0.002), ASCA IgG/IgA (OR 1.75. P = 0.002), Omp (OR 1.86 P = 0.001) Lis well as perforating, perianal disease, arthritis, ocular, and cutaneous manifestations (P = 0.002-0.032). In contrast, PAB and GAB antibodies were not associated with NOD2/CARD15 or TLR4. response to medical therapy, or need for surgery. No associations were found in UC.
Conclusions: PAB autoantibodies in combination with ASCA or anti-glycan antibodies increase the sensitivity for detecting CD, especially isolated colonic CD. Antibody response to PAB was associated with complicated disease phenotype and extraintestinal manifestations in this Eastern European IBD cohort.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Lakatos, Péter László and Altorjay, István and Szamosi, Tamás and Palatka, Károly and Vitalis, Zsuzsanna and Tumpek, Judit and Sipka, Sándor and Udvardy, Miklós and Dinya, Tamás and Lakatos, László and Kovács, Ágota and Molnár, Tamás and Tulassay, Zsolt and Miheller, Pál and Barta, Zsolt and Stocker, Winfried and Papp, János and Veres, Gábor and Papp, Mária (2009) Pancreatic Autoantibodies Are Associated with Reactivity to Microbial Antibodies, Penetrating Disease Behavior, Perianal Disease, and Extraintestinal Manifestations, But Not with NOD2/CARD15 or TLR4 Genotype in a Hungarian IBD Cohort. Inflammatory Bowel Diseases, 15 (3). pp. 365-374. ISSN 1078-0998
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