Antimicrobial susceptibility of Francisella tularensis subsp. holarctica strains from Hungary, Central Europe
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Tartalom: http://real.mtak.hu/4960/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Antimicrobial susceptibility of Francisella tularensis subsp. holarctica strains from Hungary, Central Europe
Létrehozó:
Kreizinger, Zsuzsa
Makrai, László
Helyes, Georgina
Magyar, Tibor
Erdélyi, Károly
Gyuranecz, Miklós
Dátum:
2013
Téma:
R1 Medicine (General) / orvostudomány általában
RA0421 Public health. Hygiene. Preventive Medicine / közegészségügy, higiénia, betegség-megelőzés
SV Veterinary science / állatorvostudomány
Tartalmi leírás:
Objectives: Determining the in vitro susceptibility to 11 antibiotics of Francisella tularensis subsp. holarctica
strains belonging to the phylogenetic group B.13, from different areas of Hungary.
Methods: Twenty-nine F. tularensis strains isolated between 2003 and 2010 from free-ranging European brown
hares (Lepus europaeus) and a captive patas monkey (Erythrocebus patas) were collected from different parts of
Hungary and examined for antibiotic susceptibility with commercially available MIC test strips on modified
Francis agar plates; values were interpreted according to CLSI breakpoints.
Results: The strains were susceptible to aminoglycosides (MIC90 values: gentamicin, 0.75 mg/L; and streptomycin,
6.0 mg/L), tetracyclines (MIC90 values: tetracycline, 0.5 mg/L; and doxycycline, 1.0 mg/L), quinolones (MIC90
values: ciprofloxacin, 0.047 mg/L; and levofloxacin, 0.023 mg/L) and chloramphenicol (MIC90 value: 1.5 mg/L),
i.e. antibiotics commonly used in therapy. Tigecycline (MIC90 value: 0.19 mg/L) and rifampicin (MIC90 value:
1.0 mg/L) were also active against F. tularensis strains, while resistance to erythromycin (MIC90 value:
.256 mg/L) and linezolid (MIC90 value: 32 mg/L) was observed in all strains.
Conclusions: Based on the results, quinolones are recommended as first choice therapy for F. tularensis infection.
The in vitro susceptibility of the strains to tigecycline may encourage the application of this antibiotic as
well. The similar antibiotic susceptibilities of the Hungarian strains belonging to different subclades of phylogenetic
group B.13 indicates that strains from other Central and Eastern European countries belonging to this group
might also have the same susceptibility profile.
Típus:
Article
NonPeerReviewed
Formátum:
text
Azonosító:
Kreizinger, Zsuzsa and Makrai, László and Helyes, Georgina and Magyar, Tibor and Erdélyi, Károly and Gyuranecz, Miklós (2013) Antimicrobial susceptibility of Francisella tularensis subsp. holarctica strains from Hungary, Central Europe. Journal of Antimicrobial Chemotherapy, 68. pp. 370-373.
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