Tumor Characteristics in Screen-Detected and Symptomatic Breast Cancers
  • Metaadatok
Tartalom: http://dx.doi.org/10.1007/s12253-008-9010-7
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Tumor Characteristics in Screen-Detected and Symptomatic Breast Cancers
Létrehozó:
Pálka, István
Kelemen, Gyöngyi
Ormándi, Katalin
Lázár, György
Nyári, Tibor András
Thurzó, László
Kahán, Zsuzsanna
Kiadó:
Springer
Dátum:
2008
Téma:
RB Pathology / patológia, kórtan
RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
Tartalmi leírás:
The natural course of early breast cancer has
changed as a result of the introduction of mammographic
screening. The present aim was a prospective analysis of
screen-detected and symptomatic operable breast cancers in
the era of mammographic service screening. The mode of
detection (screen-detected, symptomatic or interval cancer),
the type of mammographic image and other characteristics
(the invasive tumor size, histological tumor type, grade,
nodal, hormone receptor and HER2 status and the presence
of lymphovascular invasion) of 569 invasive breast cancers
were studied. Screen-detected cancers were significantly
more frequently of grade I, <10 mm of size and nodenegative
(p<0.001, respectively). Symptomatic/interval
cancers were significantly more frequently of grade 3,
>20 mm of size (p<0.001), and exhibited lymphovascular
invasion (p=0.001). Screening-detection of the tumor
favored breast-conserving surgery, sentinel lymph node
biopsy and the avoidance of chemotherapy (p<0.001).
Cancers associated with casting-type calcifications on the
mammogram were typically of ductal type (p=0.043), of
grade 2?3, estrogen receptor and progesterone receptornegative
and HER2-positive (p<0.001). Interval cancers
occurred significantly more often at a younger age and
remained mammographically occult as compared with other
cancers. Mammographic screen-detected cancers demonstrate
more favorable prognostic features, and need less
extensive treatment than symptomatic or interval cancers.
The mammographic appearance of the tumor reflects its
biological behavior, and this should be considered in the
management optimization.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Pálka, István and Kelemen, Gyöngyi and Ormándi, Katalin and Lázár, György and Nyári, Tibor András and Thurzó, László and Kahán, Zsuzsanna (2008) Tumor Characteristics in Screen-Detected and Symptomatic Breast Cancers. Pathology and Oncology Research, 14 (2). pp. 161-167. ISSN 1219-4956
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