The prognostic significance of HPV-16 genome status of the lymph nodes, the integration status and p53 genotype in HPV-16 positive cervical cancer: a long term follow up
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Tartalom: http://dx.doi.org/10.1016/S1470-0328(02)01916-X
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
The prognostic significance of HPV-16 genome status of the lymph nodes, the integration status and p53 genotype in HPV-16 positive cervical cancer: a long term follow up
Létrehozó:
Hernádi, Zoltán
Szarka, Krisztina Zsuzsanna
Sápy, Tamás
Krasznai, Zoárd
Veress, György
Póka, Róbert
Kiadó:
Wiley-Blackwell
Dátum:
2003
Téma:
QR355 Virology / víruskutatás
RZ Other systems of medicine / orvostudomány egyéb területei
Tartalmi leírás:
Objective Prognostic evaluation of HPV-16 genome status of the pelvic lymph nodes, the integration status of
HPV-16 and p53 codon 72 polymorphism in cervical cancer.
Design Prospective cohort study.
Setting Department of Gynaecological Oncology, University of Debrecen, Hungary.
Sample Thirty-nine patients with HPV-16 positive cervical cancer.
Methods Primary tumour specimens of 39 cervical cancer patients with HPV-16 positive primary tumour
were subjected to multiplex polymerase chain reaction using HPV-16 E1/E2, E7 and p53 codon 72 allelespecific
primers. Pelvic lymph nodes of the same patients were also tested for the presence of HPV-16 DNA
and for its integration status using HPV-16 E7 and E1/E2 ORF specific primers, respectively.
Main outcome measures Progression-free survival.
Results Metastatic lymph nodes carried HPV-16 DNA more frequently than nodes with no evidence of disease
(100.0% vs 35.7%, P ź 0.001). Cases with HPV-16 positive nodes had higher recurrence rate than those
with HPV-16 negative nodes (42.9% vs 11.1%, P ź 0.009). There was no difference between cases with and
without histologically proven nodal disease with regard to integration status of HPV-16 DNA in the primary
tumour (integrated 90.9% vs 71.4%, episomal 9.1% vs 21.4%, mixed 0% vs 7.1%) and p53 codon 72
polymorphism (Arg/Arg 54.5% vs 67.9%, Pro/Pro 0 vs 7.1%, Arg/Pro 45.5% vs 21.4%).
Conclusion Regardless of the presence of nodal metastasis, HPV-16 status of the nodes is a significant
predictor of recurrent disease. HPV-16 integration status and p53 codon 72 genotype do not seem to have a
bearing on disease outcome in cervical cancer with HPV-16 positive primary.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Hernádi, Zoltán and Szarka, Krisztina Zsuzsanna and Sápy, Tamás and Krasznai, Zoárd and Veress, György and Póka, Róbert (2003) The prognostic significance of HPV-16 genome status of the lymph nodes, the integration status and p53 genotype in HPV-16 positive cervical cancer: a long term follow up. BJOG: An International Journal of Obstetrics and Gynaecology, 110 (2). pp. 205-209. ISSN 1470-0328
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