Expression of Matrilin-2 in Liver Cirrhosis and Hepatocellular Carcinoma
  • Metaadatok
Tartalom: http://dx.doi.org/10.1007/s12253-008-9005-4
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Expression of Matrilin-2 in Liver Cirrhosis and Hepatocellular Carcinoma
Létrehozó:
Szabó, Erzsébet
Korpos, Éva
Batmunkh, Enkhjargal
Lotz, Gábor
Holczbauer, Ágnes
Kovalszky, Ilona
Deák, Ferenc
Kiss, Ibolya
Schaff, Zsuzsa
Kiss, András
Kiadó:
Springer
Dátum:
2008
Téma:
RB Pathology / patológia, kórtan
RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
Tartalmi leírás:
The recently described matrilin protein family is part of the extracellular matrix, their pathophysiological role as well as distribution in liver diseases, however, have not yet been studied. Considering that matrilins have been found to play role in cell growth and tissue remodeling, their possible involvement in carcinogenesis has been raised. The main objective of this study was to investigate the changes in matrilin-2 expression which is one of the main components of basement membranes. Thirty-five cases of surgically resected hepatocellular carcinomas, 35 corresponding surrounding liver tissues and 10 normal liver samples were used for the study. In 15 of 35 cases the tumor developed on the basis of cirrhosis. Matrilin-2 protein expression was detected in normal liver around bile ducts, portal blood vessels, while sinusoids were negative by immunohistochemistry. Cirrhotic surrounding tissue showed intensive matrilin-2 staining along the sinusoids. Tumorous neovasculature was found strongly positive by immunohistochemistry. No differences, however, were detected by morphometry regarding the amount of protein expression based on the grade of hepatocellular carcinomas. Real-time RT-PCR did not show significant differences in matrilin-2 mRNA expression between normal, cirrhotic and tumor samples. This suggests posttranslational modification of matrilin-2 manifesting in altered distribution in liver fibrosis. Our data indicate that matrilin-2 is a novel basement membrane component in the liver, which is synthetised during sinusoidal "capillarization" in cirrhosis and in hepatocellular carcinoma. This is the first report to describe the expression and distribution of matrilin-2 in human normal and cirrhotic liver as well as in hepatocellular carcinoma.
Típus:
Article
NonPeerReviewed
Formátum:
text
Azonosító:
Szabó, Erzsébet and Korpos, Éva and Batmunkh, Enkhjargal and Lotz, Gábor and Holczbauer, Ágnes and Kovalszky, Ilona and Deák, Ferenc and Kiss, Ibolya and Schaff, Zsuzsa and Kiss, András (2008) Expression of Matrilin-2 in Liver Cirrhosis and Hepatocellular Carcinoma. Pathology and Oncology Research, 14 (1). pp. 15-22. ISSN 1219-4956
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