The cellular electrophysiologic effect of a new amiodarone like antiarrhythmic drug GYKI 16638 in undiseased human ventricular muscle: comparison with sotalol and mexiletine
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Archívum: MTA Könyvtár
Gyűjtemény: Status = Published





Type = Article
Cím:
The cellular electrophysiologic effect of a new amiodarone like antiarrhythmic drug GYKI 16638 in undiseased human ventricular muscle: comparison with sotalol and mexiletine
Létrehozó:
Opincariu, M.
Varró, András
Jost, Norbert
Virág, László
Hála, O.
Szolnoky, Jenő
Szécsi, J.
Bogáts, Gábor
Szenohradszky, P.
Mátyus, Péter
Papp, Gyula
Kiadó:
Bentham Science Publishers Ltd.
Dátum:
2002
Téma:
QD Chemistry / kémia
QH3011 Biochemistry / biokémia
QH3015 Molecular biology / molekuláris biológia
RM Therapeutics. Pharmacology / terápia, gyógyszertan
RS Pharmacy and materia medica / gyógyszerészet, gyógyászati eszközök
Tartalmi leírás:
The cellular electrophysiologic effect of GYKI 16638, a new antiarrhythmic compound was studied and compared with that of sotalol and mexiletine in undiseased human right ventricular muscle preparation by applying the conventional microelectrode technique.
GYKI 16638 (5 muM), at stimulation cycle length of 1000 ms, lengthened action potential duration (APD(90)) from 338.9 +/- 28.6 ms to 385.4 +/- 24 ms (n = 9, p < 0.05). This APID lengthening effect, unlike that of sotalol (30 muM), was rate-independent. GYKI 16638, contrary to sotalol and like mexiletine (10 muM), exerted a use-dependent depression of the maximal rate of depolarization (V-max) which amounted to 36.4 +/- 11.7 % at cycle length of 400 ms (n = 5, p < 0.05) and was characterised with an offset kinetical time constant of 298.6 +/- 70.2 ms.
It was concluded that GYKI 16638 in human ventricular muscle shows combined Class IB and Class III antiarrhythmic properties, resembling the electrophysiological manifestation seen after chronic amiodarone treatment.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Opincariu, M. and Varró, András and Jost, Norbert and Virág, László and Hála, O. and Szolnoky, Jenő and Szécsi, J. and Bogáts, Gábor and Szenohradszky, P. and Mátyus, Péter and Papp, Gyula (2002) The cellular electrophysiologic effect of a new amiodarone like antiarrhythmic drug GYKI 16638 in undiseased human ventricular muscle: comparison with sotalol and mexiletine. Current Medicinal Chemistry, 9 (1). pp. 41-46. ISSN 0929-8673
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