What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart
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Tartalom: http://www2.sci.u-szeged.hu/ABS/2012/Acta%20HPb/5693.pdf
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart
Létrehozó:
Szüts, Viktória
Ötvös, Ferenc
Dézsi, László
Vágvölgyi, Csaba
Szalontai, Balázs
Dobrzynski, Halina
Boyett, Marc
Zhang, Henggui
Papp, Gyula
Varró, András
Benyhe, Sándor
Erdélyi, Lajos
Kiadó:
University of Szeged
Dátum:
2012
Téma:
R1 Medicine (General) / orvostudomány általában
RM Therapeutics. Pharmacology / terápia, gyógyszertan
Tartalmi leírás:
Two-pore domain potassium channels (K2P) control excitability, stabilize the resting
membrane potential below firing threshold, and accelerate repolarisation in different cells. Until
now, fifteen different genes for the six K2P channel subfamily were cloned. The pore-forming
part is translated from two genes and they are built up from a dimer of two two-unit transmembrane
domains functioning with a wide spectrum of physiological profiles. K2P ion channels
were discovered in the last two decades and gave novel opportunity to recognize the complex
molecular mechanism of the potassium ion flux, and may lead to the design of individual drug
targeting in the future. In this review, we summarise the structure, function, channelopathies
and pharmacological silhouette of the two-pore potassium channels in the human tissues. In
addition, we present the computer model of the partially reconstructed wild type K2P1/TWIK1
lacking the intracellular C and N terminal loops
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Szüts, Viktória and Ötvös, Ferenc and Dézsi, László and Vágvölgyi, Csaba and Szalontai, Balázs and Dobrzynski, Halina and Boyett, Marc and Zhang, Henggui and Papp, Gyula and Varró, András and Benyhe, Sándor and Erdélyi, Lajos (2012) What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart. Acta Biologica Szegediensis, 56 (2). pp. 93-107. ISSN 1588-385X
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