Visible light induces matrix metalloproteinase-9 expression in rat eye
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Tartalom: http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.20...
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Visible light induces matrix metalloproteinase-9 expression in rat eye
Létrehozó:
Papp, Andrea M.
Nyilas, Rita
Szepesi, Zsuzsanna
Lőrincz, Magor R.
Takács, Eszter
Ábrahám, István
Szilágyi, Nóra
Tóth, Júlia
Medveczky, Péter
Szilágyi, László
Juhász, Gábor
Juhász, Gábor
Kiadó:
Wiley-Blackwell
Dátum:
2007
Téma:
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
RZ Other systems of medicine / orvostudomány egyéb területei
Tartalmi leírás:
Up-regulation of matrix metalloproteinase-9 (MMP-9, gelatinase B) in the nervous system has been demonstrated when excitotoxicity-induced tissue remodeling and neuronal death occurs. Induction of MMP-9 by a natural stimulus has not been observed yet. Using RT-PCR and gelatin-zymography we demonstrated MMP-9 induction at transcriptional and protein levels in different structures of the rat eye following over-stimulation with white light. MMP-9 elevation occurred in the retina without reduction in photoreceptor number or major anatomical reorganization. A transient decrease in electroretinogram b-wave indicated the functional recovery. Retrobulbar injection of a broad-spectrum MMP-inhibitor GM6001, slowed the recovery rate of b-wave amplitude. Even room-light applied to dark-adapted awake animals induced MMP-9 increase in the retina, which suggests a role for MMP-9 in physiological functional plasticity of the nervous system, such as light adaptation. This is the first demonstration of MMP-9 induction by a sensory stimulus.
Típus:
Article
PeerReviewed
Formátum:
application/pdf
Azonosító:
Papp, Andrea M. and Nyilas, Rita and Szepesi, Zsuzsanna and Lőrincz, Magor R. and Takács, Eszter and Ábrahám, István and Szilágyi, Nóra and Tóth, Júlia and Medveczky, Péter and Szilágyi, László and Juhász, Gábor and Juhász, Gábor (2007) Visible light induces matrix metalloproteinase-9 expression in rat eye. Journal of Neurochemistry, 103 (6). pp. 2224-2233. ISSN 0022-3042 (print), 1471-4159 (online)
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